Amygdala stimulation ameliorates memory impairments and promotes c-Fos activity in fimbria-fornix-lesioned rats.,SYNAPSE

当前位置： X-MOL 学术 › Synapse › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Amygdala stimulation ameliorates memory impairments and promotes c-Fos activity in fimbria-fornix-lesioned rats.
SYNAPSE ( IF 1.6 ) Pub Date : 2020-07-04 , DOI: 10.1002/syn.22179
Daymara Mercerón-Martínez ₁ , William Almaguer-Melian ₁ , Esteban Alberti-Amador ₁ , Rául Calderón-Peña ₂ , Jorge A Bergado ₃

Affiliation

Recently we provided data showing that amygdala stimulation can ameliorate spatial memory impairments in rats with lesion in the fimbria‐fornix (FF). The mechanisms for this improvement involve early gene expression and synthesis of BDNF, MAP‐2, and GAP43 in the hippocampus and prefrontal cortex. Now we have studied which brain structures are activated by the amygdala using c‐Fos as a marker of neural activation. First, we studied neuronal activation after tetanic stimulation to the amygdala in intact rats. We then carried out a second study in FF‐lesioned rats in which the amygdala was stimulated 15 min after daily spatial memory training in the water maze. Our results showed that amygdala stimulation produces widespread brain activation, that includes cortical, thalamic, and brain stem structures. Activation was particularly intense in the dentate gyrus and the prefrontal cortex. Training in the water maze increased c‐Fos positive nuclei in the dentate gyrus of the hippocampus and in medial prefrontal cortex. Amygdala stimulation to trained FF‐lesioned rats induced an increase of neural activity in the dentate gyrus and medial prefrontal cortex relative to the FF‐lesioned, but not stimulated group, like the c‐Fos activity seen in trained control rats. Based on these and previous results we explain the mechanisms of amygdala reinforcement of neural plasticity and the partial recovery of spatial memory deficits.

中文翻译：

杏仁核刺激可以改善记忆力受损，并促进纤毛-穹隆受损大鼠的c-Fos活性。

最近，我们提供的数据表明，杏仁核刺激可以改善纤维膜穹隆（FF）病变大鼠的空间记忆障碍。这种改善的机制涉及海马和前额叶皮层中早期基因表达和BDNF，MAP-2和GAP43的合成。现在，我们使用c-Fos作为神经激活的标志物研究了杏仁核激活了哪些大脑结构。首先，我们研究了强直刺激扁桃体对完整大鼠的神经元活化作用。然后，我们在FF病变大鼠中进行了第二项研究，其中在水迷宫中每天进行空间记忆训练后15分钟，杏仁核被刺激。我们的结果表明杏仁核刺激产生广泛的大脑激活，包括皮质，丘脑和脑干结构。齿状回和前额叶皮层的激活特别强烈。在水迷宫中进行训练会增加海马齿状回和前额内侧皮层的c-Fos阳性细胞核。杏仁核对受过FF损伤的大鼠的刺激相对于受FF损伤但未受刺激的组，导致齿状回和内侧前额叶皮层神经活动的增加，就像在受过训练的对照大鼠中看到的c-Fos活性一样。基于这些和以前的结果，我们解释了杏仁核增强神经可塑性和部分恢复空间记忆缺陷的机制。杏仁核对受过FF损伤的大鼠的刺激相对于受FF损伤但未受刺激的组，导致齿状回和内侧前额叶皮层神经活动的增加，就像在受过训练的对照大鼠中看到的c-Fos活性一样。基于这些和以前的结果，我们解释了杏仁核增强神经可塑性和部分恢复空间记忆缺陷的机制。杏仁核对受过FF损伤的大鼠的刺激相对于受FF损伤但未受刺激的组，导致齿状回和内侧前额叶皮层神经活动的增加，就像在受过训练的对照大鼠中看到的c-Fos活性一样。基于这些和以前的结果，我们解释了杏仁核增强神经可塑性和部分恢复空间记忆缺陷的机制。

更新日期：2020-07-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11