IFN lambda (type III‐IFN‐λ1) is a molecule primarily produced by epithelial cells that provides an important first‐line defence against viral respiratory infections and has been linked to the pathogenesis of viral‐induced wheezing in early life. The goal of this study was to better understand the regulation of innate IFN‐lambda responses in vitro in primary human infant airway epithelial cells (AECs) and in vivo using nasal aspirates during viral respiratory infections.

中文翻译：

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人类婴儿气道上皮对 dsRNA 的先天 IFN-lambda 反应以及生命早期病毒性呼吸道感染期间的临床调节因素


IFN lambda（III-IFN-λ1）是一种主要由上皮细胞产生的分子，它提供了针对病毒性呼吸道感染的重要一线防御，并且与生命早期病毒引起的喘息的发病机制有关。本研究的目的是更好地了解体外原代人类婴儿气道上皮细胞 (AEC) 和体内病毒性呼吸道感染期间鼻吸液对先天 IFN-lambda 反应的调节。