Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity.,American Journal of Reproductive Immunology

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Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity.
American Journal of Reproductive Immunology ( IF 2.5 ) Pub Date : 2020-07-04 , DOI: 10.1111/aji.13298
Emma Björk _{1,

2,

3} , Marie-Therese Vinnars _{1,

2,

3} , Ivan Nagaev ₂ , Olga Nagaeva ₂ , Eva Lundin ₄ , Ulrika Ottander ₃ , Lucia Mincheva-Nilsson ₂

Affiliation

Endometriosis is a disease characterized by ectopic implantation of endometrium and impaired immune responses. To explore its pathogenic mechanisms, we studied the local and systemic cytokine mRNA profiles and their role in the immunity of patients with endometriosis and healthy controls.

中文翻译：

子宫内膜异位症女性局部和全身炎症细胞因子 mRNA 表达的增强会引起补偿性适应性调节 mRNA 反应，从而介导免疫抑制并削弱细胞毒性。

子宫内膜异位症是一种以子宫内膜异位着床和免疫反应受损为特征的疾病。为了探索其致病机制，我们研究了局部和全身细胞因子 mRNA 谱及其在子宫内膜异位症患者和健康对照者免疫中的作用。

更新日期：2020-07-04

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