A convenient method has been developed for the selective synthesis of N-alkoxylated benzimidazole derivatives by the cyclocondensation reaction of simple ortho-phenylenediamine, formaldehyde and alcohols in presence of indium oxide nanoparticles as catalyst. The alcohol acts as reactant as well as solvent in this reaction. No other solvents or additives have been used for this reaction. The catalyst can be reused several times without significant loss of catalytic activity. A probable reaction mechanism has been proposed based on some control experiments.

中文翻译：

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纳米氧化铟催化多米诺反应合成N-烷氧基化苯并咪唑

已经开发了一种方便的方法，用于在氧化铟纳米粒子作为催化剂的情况下，通过简单的邻苯二胺，甲醛和醇类的环缩合反应选择性合成N-烷氧基化的苯并咪唑衍生物。醇在该反应中既充当反应物又充当溶剂。没有其他溶剂或添加剂已用于该反应。催化剂可以重复使用几次，而不会明显降低催化活性。基于一些控制实验，提出了一种可能的反应机理。