Two new aromatic butenolides (1 and 2), along with a known analogue (3), were isolated and structurally identified from the fermentation extract of a mangrove sediment derived fungus Aspergillus terreus SCAU011. Structures of the new compounds were established mainly by spectroscopic data analyses, and the absolute configurations were determined by a combination of various strategies including electronic circular dichroism (ECD) comparison, induced circular dichroism (ICD) experiments and chemical derivation and degradation. Compound 2, with an unusual dimeric scaffold linked via an ether bridge, exhibited a wide range of biological properties including strong cyclooxygenase-2 (COX-2) and α-glucosidase inhibitory activities, as well as moderate antiradical and antibacterial effects.

从红树林沉积物衍生的真菌曲霉曲霉SCAU011的发酵提取物中分离并从结构上鉴定了两种新的芳族丁烯内酯（1和2）以及已知的类似物（3）。新化合物的结构主要是通过光谱数据分析确定的，其绝对构型是通过多种策略的组合来确定的，这些策略包括电子圆二色性（ECD）比较，诱导圆二色性（ICD）实验以及化学衍生和降解。化合物2，具有不寻常的二聚体支架，通过 醚桥具有广泛的生物学特性，包括强大的环氧合酶2（COX-2）和α-葡萄糖苷酶抑制活性以及适度的抗自由基和抗菌作用。