Bisphenol A (BPA) can affect reproductive function, but its mechanism of reproductive toxicity is unclear, and the effect of BPA on the onset of puberty was inconsistent. The main purpose of this study is to investigate the effects of perinatal exposure to BPA on the onset of puberty and reproductive function, and its mechanism from the aspect of autophagy and inflammation in ovarian and uterus tissues of female offspring. Twenty-one pregnant SD rats were randomly divided into three groups: Control group, 1 μg/mL BPA (LBPA) and 10 μg/mL BPA group (HBPA) via drinking water from gestational day 6 to the end of lactation. After weaning, female offspring rats were fed a normal diet and drinking water for 5 weeks. The levels of E2, LH, FSH, T, and IL-6 and TNF-α, and the onset of puberty, and morphological changes in ovarian and uterine were determined in female offspring at 8 weeks. The levels of TLR4, NF-κB, PI3K/Akt/mTOR and autophagy related protein in uterine tissue were also detected. Our results indicated that perinatal exposure to BPA advanced puberty, which was associated with increased serum E2, LH and FSH levels. There was a significantly thin endometrium epithelium in HBPA group compared with control group, which may affect reproductive function. The adverse effect of perinatal BPA exposure on reproductive function maybe was associated with the activation of inflammation and abnormal autophagy via TLR4/NF-κB and mTOR signaling pathways respectively in female offspring.

双酚A（BPA）可影响生殖功能，但其生殖毒性机制尚不清楚，且BPA对青春期开始的影响也不一致。本研究的主要目的是从雌性子代卵巢和子宫组织自噬和炎症等方面探讨围产期BPA暴露对青春期开始和生殖功能的影响及其机制。将21只妊娠SD大鼠随机分为3组：对照组、1 μg/mL BPA（LBPA）和10 μg/mL BPA组（HBPA），从妊娠第6天至哺乳结束期间饮水。断奶后，雌性子代大鼠正常饮食和饮水5周。 8周时测定雌性后代的E2、LH、FSH、T、IL-6和TNF-α的水平、青春期的开始以及卵巢和子宫的形态变化。检测子宫组织中TLR4、NF-κB、PI3K/Akt/mTOR及自噬相关蛋白的含量。我们的结果表明，围产期接触 BPA 会使青春期提前，这与血清 E2、LH 和 FSH 水平升高有关。与对照组相比，HBPA组子宫内膜上皮明显变薄，可能影响生殖功能。围产期 BPA 暴露对生殖功能的不利影响可能与雌性子代炎症激活和 TLR4/NF-κB 和 mTOR 信号通路异常自噬有关。