Autophagy is a major self-degradative intracellular process required for the maintenance of homeostasis and promotion of survival in response to starvation. It plays critical roles in a large variety of physiological and pathological processes. On the other hand, aberrant regulation of autophagy can lead to various cancers and neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Crohn’s disease. Emerging evidence strongly supports that epigenetic signatures, related non-coding RNA profiles, and their cross-talking are significantly associated with the control of autophagic responses. Therefore, it may be helpful and promising to manage autophagic processes by finding valuable markers and therapeutic approaches. Although there is a great deal of information on the components of autophagy in the cytoplasm, the molecular basis of the epigenetic regulation of autophagy has not been completely elucidated. In this review, we highlight recent research on epigenetic changes through the expression of autophagy-related genes (ATGs), which regulate autophagy, DNA methylation, histone modifications as well as non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and their relationship with human diseases, that play key roles in causing autophagy-related diseases.

自噬是维持体内平衡和促进饥饿生存所需的主要自我降解细胞内过程。它在各种各样的生理和病理过程中起着关键作用。另一方面，自噬的异常调节会导致各种癌症和神经退行性疾病，如阿尔茨海默病、帕金森病和克罗恩病。新出现的证据强烈支持表观遗传特征、相关的非编码 RNA 谱及其串扰与自噬反应的控制显着相关。因此，通过寻找有价值的标志物和治疗方法来管理自噬过程可能是有帮助和有希望的。虽然关于细胞质中自噬成分的信息很多，自噬表观遗传调控的分子基础尚未完全阐明。在这篇综述中，我们重点介绍了最近通过自噬相关基因表达对表观遗传变化的研究(ATGs)调节自噬、DNA 甲基化、组蛋白修饰以及非编码 RNA，包括长链非编码 RNA (lncRNA)、微小 RNA (miRNA) 及其与人类疾病的关系，在引起自噬中起关键作用。相关疾病。