Physiological experiments and computational models both show that the thalamic reticular nucleus (RE) participates in inducing various firing patterns of cortex. Absence seizure, featured by 2–4 Hz spike-wave discharges (SWD) oscillation, is a high incidence of disease in children. Lots of electrophysiological experiments have verified the correlation between absence seizures and RE, however, the dynamical mechanisms are not well understood. Based on previous Taylor model, we firstly study the effects of external input and self-inhibition of RE on epilepsy transition. We show that increasing external input and self-inhibition of RE can lead the system from epileptic state to normal state, and vice versa. Next, we explore two stimulus strategies added in RE and various transition behaviors can be induced, such as high saturated state to clonic. Meanwhile, as the intensity of stimulation increasing, they can not only suppress the SWD, but also produce tonic–clonic oscillation. Finally, the control of DBS on single neuron cluster and two neuron clusters are compared and we find stimulating RE and TC simultaneously is a superior mode to stimulate anyone of RE or TC. It is hoped that the results we obtained will have an enlightenment on clinical treatment.

生理实验和计算模型均表明，丘脑网状核（RE）参与诱导皮质的各种放电模式。缺席发作以2–4 Hz尖峰波放电（SWD）振荡为特征，是儿童疾病的高发率。许多电生理学实验已经证实了癫痫发作与RE之间的相关性，但是，其动力学机制尚不清楚。在以前的泰勒模型的基础上，我们首先研究了外部输入和RE的自我抑制对癫痫过渡的影响。我们表明，增加外部输入和RE的自我抑制可以导致系统从癫痫状态转变为正常状态，反之亦然。接下来，我们探索添加到RE中的两种刺激策略，可以诱发各种过渡行为，例如从高饱和状态到阵挛状态。同时，随着刺激强度的增加，它们不仅可以抑制SWD，还可以产生强直-阵阵振荡。最后，比较了单个神经元簇和两个神经元簇上DBS的控制，我们发现同时刺激RE和TC是刺激任何RE或TC的优越模式。希望我们获得的结果对临床治疗有启发。