Since decades, cyclodextrins are one of the most powerful selectors in chiral capillary electrophoresis for the enantioseparation of diverse organic compounds. This review concerns papers published over the last decade (from 2009 until nowadays), dealing with the capillary electrophoretic application of single isomer cyclodextrin derivatives in chiral separations. Following a brief overview of their synthetic approaches, the inventory of the neutral, negatively and positively charged (including both permanently ionic and pH-tunable ionizable substituents) and zwitterionic CD derivatives is presented, with insights to underlying structural aspects by NMR spectroscopy and molecular modeling. CE represents an ideal tool to study the weak, non-covalent supramolecular interactions. The published methods are reviewed in the light of enantioselectivity, enantiomer migration order and the fine-tuning of enantiodiscrimination by the substitution pattern of the single entity selector molecules, which is hardly possible for their randomly substituted counterparts. All the reviewed publications herein support that cyclodextrin-based chiral capillary electrophoresis seems to remain a popular choice in pharmaceutical and biomedical analysis.

数十年来，环糊精是手性毛细管电泳中对映分离各种有机化合物的最有力的选择剂之一。这篇综述涉及过去十年（从2009年至今）发表的有关单一异构体环糊精衍生物在手性分离中的毛细管电泳应用的论文。在简要概述了它们的合成方法之后，列出了中性，带负电和带正电（包括永久性离子和pH可调性可离子化取代基）和两性离子CD衍生物的清单，并通过NMR光谱学和分子建模深入了解了潜在的结构方面。CE是研究弱的非共价超分子相互作用的理想工具。根据对映选择性对已发表的方法进行了综述，对映体的迁移顺序和通过单实体选择分子的取代模式对对映异构的微调，这对于它们的随机取代的对等体几乎是不可能的。本文中所有已审阅的出版物均支持基于环糊精的手性毛细管电泳似乎仍是药物和生物医学分析中的流行选择。