Renal cell carcinoma is one of the most common malignancies with high morbidity and mortality. STAT proteins play a significant role in cell biological behavior and immune response associated with cancer progression. In our study, the datasets analyzed for the expression and potential functions can be found in several bioinformatics analysis tools. We found that STAT1/2/4/6 were upregulated in RCC while STAT3/5B were downregulated. The expression of STAT2/4/5B were significantly associated with the pathological stage of RCC patients. RCC patients with high expression of STAT2/4 and low/medium expression of STAT5B had a poor overall survival. The function of STATs and the neighboring genes mainly enriched in JAK-STAT signaling pathway and NOD-like receptor signaling pathway. Several transcription factor, kinase, and miRNA targets were identified. Close correlations were obtained between immune cell infiltration and STATs in RCC. Our results have provided novel insights for the selection of immunotherapeutic targets and prognostic biomarkers.

肾细胞癌是最常见的恶性肿瘤之一，发病率和死亡率都很高。STAT 蛋白在与癌症进展相关的细胞生物学行为和免疫反应中发挥重要作用。在我们的研究中，用于表达和潜在功能分析的数据集可以在几种生物信息学分析工具中找到。我们发现 STAT1/2/4/6 在 RCC 中上调而 STAT3/5B 下调。STAT2/4/5B的表达与RCC患者的病理分期显着相关。STAT2/4 高表达和 STAT5B 低/中表达的 RCC 患者总体生存率较差。STATs及其邻近基因的功能主要富集于JAK-STAT信号通路和NOD样受体信号通路。鉴定了几个转录因子、激酶和 miRNA 靶标。在 RCC 中，免疫细胞浸润与 STATs 之间获得了密切的相关性。我们的研究结果为选择免疫治疗靶点和预后生物标志物提供了新的见解。