Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that lack a 5′ end cap or a 3′ end poly-(A) tail and form a circular structure through covalent bonds. Compared to linear RNAs, circRNAs are more conservative and stable, and their distribution is spatiotemporally regulated. circRNAs, as a new type of competitive endogenous RNA (ceRNA), are involved in many disease processes and are also related to the occurrence and development of tumors. Over the past three years, the role of circRNAs in hematological malignancies has received increasing attention. Related research has shown that circRNAs may regulate the occurrence and development of hematological malignancies and contribute to drug resistance through a variety of molecular mechanisms. Therefore, to lay the foundation and point out directions for further research on circRNAs, this article systematically reviews the research progress on circRNAs in leukemia, lymphoma, and myeloma.

环状RNA（circRNA）是一类没有5'端帽或3'端poly-（A）尾并通过共价键形成环状结构的非编码RNA（ncRNA）。与线性 RNA 相比，circRNA 更加保守和稳定，其分布受时空调控。circRNAs作为一种新型的竞争性内源性RNA（ceRNA），参与多种疾病过程，也与肿瘤的发生发展有关。近三年来，circRNAs在血液系统恶性肿瘤中的作用越来越受到关注。相关研究表明，circRNAs可能通过多种分子机制调控血液系统恶性肿瘤的发生发展，促进耐药。因此，为进一步研究circRNA奠定基础和指明方向，