Gene ( IF 2.6 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.gene.2020.144927 Yu Tian 1 , Yao Sun 2 , Jiamin Wu 2 , Zichao Xiong 2 , Fanglin Niu 2 , Haiyue Li 2 , Yuanwei Liu 2 , Jianfeng Liu 2 , Junhong Cai 3
Aim
The incidence of head and neck cancer (HNC) is increasing but its pathogenic factors are complex. Changes in both internal (genetic) and external (environmental) causes HNC to some extent. The purpose of our study was to investigate the influence of IL1R1 polymorphisms on HNC risk in Chinese Han population.
Methods
Genotypes of 535 HNC patients and 538 healthy controls were analyzed by Agena MassARRAY. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated by logistic regression analysis to evaluate the relationship between single nucleotide polymorphisms (SNPs) and HNC susceptibility.
Results
It was found that the rs956730 of IL1R1 reduced the risk of HNC in multiple models (allele: OR = 0.76, 95% CI: 0.62–0.93, p = 0.008; codominant: OR = 0.43, 95% CI: 0.25–0.75, p = 0.003; recessive: OR = 0.45, 95% CI: 0.26–0.77, p = 0.004; additive: OR = 0.77, 95% CI: 0.63–0.94, p = 0.01). IL1R1 rs956730 had a protective effect on HNC at age ≤ 46. However, the rs3917225 increased a 1.31-fold HNC risk in the codominant model (OR = 1.31, 95% CI: 1.00–1.70, p = 0.03).
Conclusion
Our study showed that the rs956730 of IL1R1 gene in Chinese Han population was associated with a reduced risk of HNC, while the rs3917225 of IL1R1 might increase the risk of HNC.