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Authentication, phytochemical characterization and anti-bacterial activity of twoArtemisiaspecies.
Food Chemistry ( IF 8.5 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.foodchem.2020.127458
Meng-Ting Yang , Tien-Fen Kuo , Kuo-Fang Chung , Yu-Chuan Liang , Chu-Wen Yang , Chih-Yu Lin , Ching-Shan Feng , Zeng-Weng Chen , Tsung-Han Lee , Chiao-Ling Hsiao , Wen-Chin Yang

Artemisia species are aromatic herbs used as food and/or ethnomedicine worldwide; however, the use of these plants is often impeded by misidentification. Here, molecular and chemotaxonomic approaches were combined to assist in the morphology-based authentication of Artemisia species, and Artemisia indica and Artemisia argyi were identified. The plant extracts and compounds obtained from these species, 1,8-cineole, carveol, α-elemene, α-farnesene, methyl linolenate, diisooctyl phthalate inhibited the growth of food-borne harmful bacteria. Mechanistic studies showed that the extract and active compounds of A. indica killed Gram-negative and -positive bacteria via destruction of the bacterial membrane. Finally, in vivo data demonstrated that A. indica protected against bacterial infection in mice as evidenced by survival rate, bacterial load in organs, gut pathology, diarrhea, body weight, food consumption, stool weight, and pathology score. A. indica and its active compounds have potential for use as food supplements for food-borne bacterial diseases and thus improve human health.



中文翻译:

两种蒿属的鉴定,植物化学特征和抗菌活性。

青蒿是世界范围内用作食品和/或民族药典的芳香草药;但是,错误识别通常会阻碍这些植物的使用。在这里,结合了分子和化学分类方法,以协助基于形态的青蒿种鉴定,并鉴定出了印度青蒿艾蒿。从这些物种获得的植物提取物和化合物,1,8-桉树脑,香芹酚,α-榄香烯,α-法呢烯,亚油酸甲酯,邻苯二甲酸二异辛酯抑制了食源性有害细菌的生长。机理研究表明,印度的提取物和活性化合物通过破坏细菌膜杀死了革兰氏阴性和阳性细菌。最后,体内数据表明,存活率,器官中的细菌载量,肠道病理,腹泻,体重,食物消耗,粪便重量和病理评分证明了印度A虫对小鼠的细菌感染具有保护作用。曲霉及其活性化合物有潜力用作食源性细菌疾病的食品补充剂,从而改善人类健康。

更新日期:2020-07-13
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