The existing information supports the use of this material as described in this safety assessment. Phenylethyl anthranilate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from phenylethyl anthranilate and the read-across analog cinnamyl anthranilate (CAS # 87-29-6) show that phenylethyl anthranilate is not expected to be genotoxic. The skin sensitization endpoint was completed using the DST for non-reactive materials (900 μg/cm²); exposure is below the DST. The reproductive and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class II material, and the exposure to phenylethyl anthranilate is below the TTC (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on read-across analogs phenethyl alcohol (CAS # 60-12-8) and anthranilic acid (CAS # 118-92-3) provide a calculated MOE >100 for the repeated dose and developmental toxicity endpoints. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; phenylethyl anthranilate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; phenylethyl anthranilate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

现有信息支持本安全评估中所述材料的使用。评估邻氨基苯甲酸苯乙酯的遗传毒性，重复剂量毒性，发育和生殖毒性，局部呼吸毒性，光毒性/光致敏性，皮肤致敏性和环境安全性。邻氨基苯甲酸苯乙基酯和交叉阅读的邻氨基苯甲酸肉桂基酯（CAS＃87-29-6）的数据表明，邻氨基苯甲酸苯乙基酯不具有遗传毒性。使用DST对非活性物质（900μg/ cm ²）; 曝光低于DST。对于Cramer II类物质，使用TTC评估了生殖和局部呼吸毒性的终点，邻氨基苯甲酸苯乙酯的暴露低于TTC（分别为0.009 mg / kg /天和0.47 mg /天）。跨类似物苯乙醇（CAS＃60-12-8）和邻氨基苯甲酸（CAS＃118-92-3）的数据提供了重复剂量和发育毒性终点的计算出的MOE> 100。基于UV光谱评估了光毒性/光致敏性终点。邻氨基苯甲酸苯乙酯预计不会具有光毒性/光致敏性。评估了环境指标；根据IFRA环境标准，邻氨基苯甲酸苯乙酯不是PBT，根据其在欧洲和北美的当前使用量（即PEC / PNEC），其风险商小于1。