The existing information supports the use of this material as described in this safety assessment. 2-Acetylthiazole was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-acetylthiazole is not genotoxic. The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm²); exposure is below the DST. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class II material, and the exposure to 2-acetylthiazole is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; 2-acetylthiazole is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated, 2-acetylthiazole was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current Volume of Use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]) are <1.

现有信息支持本安全评估中所述的此材料的使用。对2-乙酰噻唑的遗传毒性，重复剂量毒性，生殖毒性，局部呼吸毒性，光毒性/光致过敏性，皮肤致敏性和环境安全性进行了评估。数据表明2-乙酰基噻唑没有遗传毒性。使用非反应性物质（900μg/ cm ²的皮肤致敏性阈值（DST））完成皮肤致敏性终点）; 曝光低于DST。使用Cramer II类物质的毒理学阈值（TTC）评估重复剂量，生殖和局部呼吸道毒性终点，并且2-乙酰基噻唑的暴露低于TTC（0.009 mg / kg /天，0.009 mg / kg /天和0.47毫克/天）。基于UV光谱评估了光毒性/光致敏性终点。预计2-乙酰基噻唑不会具有光毒性/光致敏性。根据国际香水协会（IFRA）环境标准及其当前的欧洲和欧洲使用量，对环境指标进行了评估，发现2-乙酰基噻唑不是持久性，生物蓄积性和有毒的（PBT）。北美（即，