The existing information supports the use of this material as described in this safety assessment. Ethyl 3-methylthiopropionate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl 3-methylthiopropionate (CAS # 13532-18-8) show that ethyl 3-methylthiopropionate is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to ethyl 3-methylthiopropionate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 μg/cm²); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; ethyl 3-methylthiopropionate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; ethyl 3-methylthiopropionate was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current Volume of Use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

现有信息支持本安全评估中所述材料的使用。评价3-甲基硫代丙酸乙酯的遗传毒性，重复剂量毒性，生殖毒性，局部呼吸毒性，光毒性/光致敏性，皮肤致敏性和环境安全性。交叉阅读的类似物3-甲基硫代丙酸甲酯（CAS＃13532-18-8）的数据表明，预期3-甲基硫代丙酸乙酯不具有遗传毒性。使用Cramer I类物质的毒理学阈值（TTC）对重复剂量，生殖和局部呼吸毒性终点进行了评估，并且3-甲基硫代丙酸乙酯的暴露低于TTC（0.03 mg / kg /天，0.03毫克/千克/天和1.4毫克/天）。使用对非反应性物质（900μg/ cm ²的皮肤敏化阈值（DST））完成皮肤敏化终点）; 曝光低于DST。基于紫外线（UV）光谱评估了光毒性/光致敏性终点；3-甲基硫代丙酸乙酯预计不会具有光毒性/光致敏性。评估了环境指标；根据国际香水协会（IFRA）环境标准及其风险商，根据其目前在欧洲和北美的使用量，发现3-甲基硫代丙酸乙酯不具有持久性，生物蓄积性和毒性（PBT）。预测的环境浓度/预测的无效浓度[PEC / PNEC]）小于1。