Viruses continue to be a major threat to human health. In the last century, pandemics occurred and resulted in significant mortality and morbidity. Natural products have been largely screened as source of inspiration for new antiviral agents. Within the huge class of plant secondary metabolites, resveratrol-derived stilbenoids present a wide structural diversity and mediate a great number of biological responses relevant for human health. However, whilst the antiviral activity of resveratrol has been extensively studied, little is known about the efficacy of its monomeric and oligomeric derivatives. The purpose of this review is to provide an overview of the achievements in this field, with particular emphasis on the source, chemical structures and the mechanism of action of resveratrol-derived stilbenoids against the most challenging viruses. The collected results highlight the therapeutic versatility of stilbene-containing compounds and provide a prospective insight into their potential development as antiviral agents.

病毒仍然是人类健康的主要威胁。在上个世纪，大流行病发生并导致了显着的死亡率和发病率。天然产品已被广泛筛选为新型抗病毒药物的灵感来源。在大量的植物次生代谢产物中，白藜芦醇衍生的芪类化合物具有广泛的结构多样性，并介导与人类健康相关的大量生物反应。然而，虽然白藜芦醇的抗病毒活性已得到广泛研究，但对其单体和寡聚衍生物的功效知之甚少。这篇综述的目的是概述该领域的成就，特别强调白藜芦醇衍生的芪类化合物对最具挑战性病毒的来源、化学结构和作用机制。