The group of persistent organic pollutants (POPs) are particularly dangerous for the environment and by consequence for human health because of the risk to be transmitted in the food chain. Among them, the urgent problem of obsolete and forbidden organochlorinated pesticides (OCPs) needs a rigorous management in many countries, including Kazakhstan.

The aim of our study was to evaluate the effect of pesticides content in food products on the genetic status and health of the population living on the contaminated areas near destroyed warehouses for OCPs (4 villages of Talgar district and 1 control site, Almaty region).

The food products sampled in Taukaraturyk (control site), and in 4 villages where non-utilized obsolete pesticides were discovered: Beskainar, Kyzylkairat, Amangeldy, and Belbulak. The contents of 24 pesticides in food products from plant (apples, pears, tomatoes, cucumbers, sweet peppers) and animal (beef meat, cow milk, honey) origin, that grown in places of localization of non-utilized OCPs, were determined, sometimes in high and unacceptably high concentrations (before 2500 times over MRL). In pears, the pesticides content (especially DDT, γ-HCH, β-HCH, endosulfan, and aldrin pesticide group), was higher than in other fruits. Among vegetables, the highest levels of all groups of pesticide were found in cucumbers. Beef meat samples demonstrated increased contents of β-HCH, γ-HCH, endrin and dieldrin. In cow milk samples only the high concentration of dieldrin was found. The content of pesticides in meat was 4–5 times higher than in milk. The medical examinations, carried out among the cohorts living around the polluted by pesticides territories and control cohort from ecologically favorable village, showed that there were more individuals with high and middle levels of somatic health in the control group than in groups exposed to OCPs. The long-term effect of the pesticide contamination of the environment on genetic status of the population was assessed by chromosomal aberration (CA) frequencies. The highest level of chromosomal aberrations was identified for the examined residents of Kyzylkairat (41%) and Belbulak (38%), a high level in Amangeldy (12%), and middle level in Beskainar (6.5%). The association between the CA frequency, health status and the pesticides contents in food were assessed by a Spearman rank correlation. The low indicators of somatic health status were strictly associated with high levels of CA, and good health status indicates that the CA rates did not exceed the spontaneous level of mutagenesis. The strongest correlation was shown between high levels of chromosomal aberrations and the content of different pesticides in pears (Cr = 0.979–0.467), tomatoes (Cr = 0.877–0.476), cucumbers (Cr = 0.975–0.553) and meat (Cr = 0.839–0.368). The obtained results highlight the need to improve health protection by increasing the public awareness to the security of the storage of obsolete OCPs in order to strengthen food safety by efficient control services.

持久性有机污染物（POPs）对环境尤其有害，因为其在食物链中可能传播，因此对人类健康尤其有害。其中，在包括哈萨克斯坦在内的许多国家中，迫切需要淘汰和禁用有机氯农药（OCPs）这一紧迫问题。

我们的研究目的是评估食品中农药含量对OCP破坏仓库附近受污染区域（阿拉木图地区Talgar区的4个村庄和1个控制点）的居民的遗传状况和健康的影响。

在Taukaraturyk（控制点）以及发现未利用的过时农药的4个村庄中采样的食品：Beskainar，Kyzylkairat，Amangeldy和Belbulak。确定了在未利用OCPs定位的地方种植的植物（苹果，梨，西红柿，黄瓜，甜椒）和动物（牛肉，牛乳，蜂蜜）来源的食品中24种农药的含量，有时是高浓度和不可接受的高浓度（比MRL高2500倍）。梨中的农药含量（尤其是滴滴涕，γ-六氯环己烷，β-六氯环己烷，硫丹和艾氏剂农药组）高于其他水果。在蔬菜中，黄瓜中所有农药类别的含量最高。牛肉样品中的β-六氯环己烷，γ-六氯环己烷，异狄氏剂和狄氏剂含量增加。在牛奶样品中，仅发现高浓度的狄氏剂。肉中农药的含量比牛奶高4-5倍。对居住在受农药领土污染的人群和来自生态有利村庄的对照人群进行的医学检查显示，与接触OCP的人群相比，对照组中具有较高和中等水平身体健康状况的人群更多。通过染色体畸变（CA）频率评估了环境中农药污染对人群遗传状况的长期影响。对于被检查的Kyzylkairat（41％）和Belbulak（38％），Amangeldy（12％）和Beskainar（6.5％）中等水平的居民，确定了最高的染色体畸变水平。CA频率之间的关联，通过Spearman等级相关性评估食品的健康状况和农药含量。身体健康状况的低指标与高水平的CA严格相关，良好的健康状态表明CA率未超过诱变的自发水平。高水平的染色体畸变与梨（Cr = 0.979-0.467），番茄（Cr = 0.877-0.476），黄瓜（Cr = 0.975-0.553）和肉类（Cr = 0.839）中不同农药含量之间的最大相关性–0.368）。获得的结果突出表明，有必要通过提高公众对陈旧OCP的存储安全性的认识来改善健康保护，以通过有效的控制服务来加强食品安全。身体健康状态的低指标与高水平的CA严格相关，良好的健康状态表明CA率未超过诱变的自发水平。高水平的染色体畸变与梨（Cr = 0.979-0.467），西红柿（Cr = 0.877-0.476），黄瓜（Cr = 0.975-0.553）和肉类（Cr = 0.839）中不同农药含量之间的最大相关性–0.368）。获得的结果突出表明，有必要通过提高公众对陈旧OCP的存储安全性的认识来改善健康保护，以通过有效的控制服务来加强食品安全。身体健康状态的低指标与高水平的CA严格相关，良好的健康状态表明CA率未超过诱变的自发水平。高水平的染色体畸变与梨（Cr = 0.979-0.467），西红柿（Cr = 0.877-0.476），黄瓜（Cr = 0.975-0.553）和肉类（Cr = 0.839）中不同农药含量之间的最大相关性–0.368）。获得的结果突出表明，有必要通过提高公众对陈旧OCP的存储安全性的认识来改善健康保护，以通过有效的控制服务来加强食品安全。高水平的染色体畸变与梨（Cr = 0.979-0.467），西红柿（Cr = 0.877-0.476），黄瓜（Cr = 0.975-0.553）和肉类（Cr = 0.839）中不同农药含量之间的最大相关性–0.368）。获得的结果突出表明，有必要通过提高公众对陈旧OCP的存储安全性的认识来改善健康保护，以通过有效的控制服务来加强食品安全。高水平的染色体畸变与梨（Cr = 0.979-0.467），西红柿（Cr = 0.877-0.476），黄瓜（Cr = 0.975-0.553）和肉类（Cr = 0.839）中不同农药含量之间的最大相关性–0.368）。获得的结果突出表明，有必要通过提高公众对陈旧OCP的存储安全性的认识来改善健康保护，以通过有效的控制服务来加强食品安全。