Pulmonary tuberculosis (TB) is one of the common risk factors for chronic pulmonary aspergillosis (CPA). A positive Aspergillus IgG is a key element of the diagnosis of CPA but this has not been studied in Indonesia. We conducted studies with patients at the end of TB therapy in Indonesia. We performed receiver operating curve (ROC) analysis to determine the optimum cutoff of the Aspergillus-specific IgG level (Immulite and Dynamiker ELISA) in those patients who met criteria of CPA in relation to control groups. In 203 TB patients, 26 (13%) patients had clinical and radiological features of CPA. We derived optimum cutoffs for Immulite Aspergillus-specific IgG of 11.5 mg/L and Dynamiker anti-galactomannan IgG of 106.8 AU/mL (sensitivity 89% and 83%, specificity 78% and 51%, respectively). The currently accepted Aspergillus-specific IgG cutoff of Immulite and Dynamiker assays for CPA diagnosis may require slight adjustment for the Indonesian population.

肺结核（TB）是慢性肺曲霉病（CPA）的常见危险因素之一。曲霉菌IgG阳性是诊断 CPA 的关键因素，但印度尼西亚尚未对此进行研究。我们在印度尼西亚对结核病治疗结束时的患者进行了研究。我们进行了受试者工作曲线 (ROC) 分析，以确定与对照组相关的符合 CPA 标准的患者中曲霉特异性IgG 水平（Immulite 和 Dynamiker ELISA）的最佳截止值。在 203 名 TB 患者中，26 名（13%）患者具有 CPA 的临床和放射学特征。我们得出了 Immulite Aspergillus 特异性的最佳截止值IgG 为 11.5 mg/L，Dynamiker 抗半乳甘露聚糖 IgG 为 106.8 AU/mL（灵敏度分别为 89% 和 83%，特异性分别为 78% 和 51%）。目前公认的用于 CPA 诊断的 Immulite 和 Dynamiker 检测的曲霉特异性IgG 截止值可能需要对印度尼西亚人群进行轻微调整。