Starvation therapy (ST) and chemodynamic therapy (CDT) are emerging tumor therapy methods in recent years. In this study, a simple approach was reported to prepare MoS₂ and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe³⁺ (MAF) hydrogel. In the hydrogel, there exists an enzymatic reaction to consume glucose to form hydrogen peroxide (H₂O₂), and a redox reaction between Fe³⁺ and MoS₂ to form Fe²⁺ and MoO₄²⁻. The formed Fe²⁺ could be oxidized to Fe³⁺, which reacts with MAF hydrogel again to continuously produce Fe²⁺. The consumption of glucose resulted in an obvious tumor ST. Moreover, the produced Fe²⁺ induced a Fenton reaction to enable the persistent conversion of H₂O₂ to cytotoxic hydroxyl radicals (·OH) for the CDT of tumors. Together with the high photothermal transforming capability of MoS₂, the hydrogel was used for the combined tumor photothermal therapy (PTT), ST, and CDT. This work provides a window for the safe use of enzymes for achieving high tumor therapeutic efficacy.

饥饿疗法（ST）和化学动力学疗法（CDT）是近年来新兴的肿瘤治疗方法。在这项研究中，报道了一种简单的方法来制备含 MoS ₂和葡萄糖氧化酶 (GOx) 的海藻酸钠 (ALG)-Fe ³⁺ (MAF) 水凝胶。在水凝胶中，存在消耗葡萄糖形成过氧化氢（H ₂ O ₂）的酶促反应，以及Fe ³⁺和MoS ₂之间的氧化还原反应生成Fe ²⁺和MoO ₄ ^2-。生成的 Fe ²⁺可被氧化成 Fe ³⁺，再与 MAF 水凝胶反应生成 Fe ²⁺. 葡萄糖的消耗导致明显的肿瘤ST。此外，产生的Fe ²⁺诱导芬顿反应，使H ₂ O ₂持续转化为细胞毒性羟基自由基（·OH），用于肿瘤的CDT。结合MoS ₂的高光热转化能力，该水凝胶用于联合肿瘤光热疗法（PTT）、ST 和CDT。这项工作为安全使用酶以实现高肿瘤治疗效果提供了一个窗口。