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Preparation of a Novel Sustained-release System for Pyrethroids by Using Metal-Organic Frameworks (MOFs) Nanoparticle
Colloids and Surfaces A: Physicochemical and Engineering Aspects ( IF 4.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.colsurfa.2020.125266
Wenyan Meng , Zhenfen Tian , Pengji Yao , Xialun Fang , Tong Wu , Jiagao Cheng , Aihua Zou

Abstract In recent years, metal-organic frameworks (MOFs), especially nanoscale metal-organic frameworks (NMOFs) have been arisen as potential platform for delivery and sustained-release of drug molecules due to their excellent encapsulation performance. While, NMOFs used as carriers for pesticides have rarely been reported. Nanoscale UiO-66 had the potential to be used as a pesticide carrier due to its outstanding chemical and thermal stability, non-toxic and mass-production. In this work, lambda-cyhalothrin (LC) molecules were encapsulated in the nanoscale UiO-66 (LC@UiO-66) with ultrahigh drug loading (87.71 %) and good sustained-release property. The drug loading of LC@UiO-66 was higher than that of ever reported. LC@UiO-66 nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis measurements (TGA) and nitrogen adsorption-desorption isotherms. LC@UiO-66 nanoparticles had the cubic shape with an average particle size around 270 nm. The bioassay against Musca domestica (hygiene pests) showed that LC@UiO-66 had long-term insecticidal effect compared to the free LC and commercially available microcapsules, and the insecticidal activity of LC@UiO-66 was superior to commercially available microcapsules. Furthermore, LC@UiO-66 had an effective insecticidal effect against Aphis craccivora Koch (agricultural pests). All the above results demonstrated that LC@UiO-66 had excellent insecticidal effect in both public hygiene and agriculture. This study could expand the application of NMOFs as novel carriers for pesticides.

中文翻译:

使用金属有机骨架 (MOF) 纳米颗粒制备新型拟除虫菊酯缓释系统

摘要 近年来,金属有机骨架(MOFs),尤其是纳米级金属有机骨架(NMOFs)由于其优异的包封性能而成为药物分子递送和缓释的潜在平台。而作为农药载体的NMOFs却鲜有报道。纳米级 UiO-66 由于其出色的化学和热稳定性、无毒和可大规模生产而具有用作农药载体的潜力。在这项工作中,λ-三氯氟氰菊酯 (LC) 分子被封装在纳米级 UiO-66 (LC@UiO-66) 中,具有超高的载药量 (87.71%) 和良好的缓释性能。LC@UiO-66 的载药量高于以往报道的载药量。LC@UiO-66 纳米粒子通过 X 射线衍射 (XRD)、透射电子显微镜 (TEM)、傅立叶变换红外 (FT-IR) 光谱、热重分析测量 (TGA) 和氮吸附-解吸等温线。LC@UiO-66 纳米颗粒呈立方体形状,平均粒径约为 270 nm。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。热重分析测量 (TGA) 和氮吸附-解吸等温线。LC@UiO-66 纳米颗粒呈立方体形状,平均粒径约为 270 nm。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。热重分析测量 (TGA) 和氮吸附-解吸等温线。LC@UiO-66 纳米颗粒呈立方体形状,平均粒径约为 270 nm。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。LC@UiO-66 纳米颗粒呈立方体形状,平均粒径约为 270 nm。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。LC@UiO-66 纳米颗粒呈立方体形状,平均粒径约为 270 nm。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。对家蝇(卫生害虫)的生物测定表明,LC@UiO-66与游离LC和市售微胶囊相比具有长期杀虫作用,LC@UiO-66的杀虫活性优于市售微胶囊。此外,LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。LC@UiO-66对Aphis craccivora Koch(农业害虫)具有有效的杀虫作用。以上结果表明LC@UiO-66在公共卫生和农业方面均具有优异的杀虫效果。该研究可以扩大NMOFs作为农药新型载体的应用。
更新日期:2020-11-01
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