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Nanoparticle-based 3D membrane for impedimetric biosensor applications.
Bioelectrochemistry ( IF 4.8 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.bioelechem.2020.107593
Lu Cao 1 , Janice Kiely 1 , Martina Piano 1 , Richard Luxton 1
Affiliation  

This paper reports on a comparison between nano-ZnO/CuO and nano-ZnO nitrocellulose membrane biosensors, both of which were fabricated using a simple and inexpensive sonication technique. To produce the nano-ZnO/CuO membranes, the technique involved sonication of 1% (w/v) ZnO and 1% (w/v) CuO nano-crystal colloidal suspensions, with a volume ratio of 1:2. The membranes were analysed by scanning electron microscopy and energy-dispersive spectroscopy, which showed the gradated distribution of nanoparticles in the membrane. Impedance spectroscopy demonstrated that the sonication resulted in a greater than two-fold enhancement of the output signal. Changes in impedance phase values, at a frequency of 100 Hz, were used to establish dose dependent responses for C-reactive protein (CRP). Limits of detection of 27 pg/mL for the 1% (w/v) nano-ZnO and 16 pg/mL for the 1% (w/v) nano-ZnO/CuO nitrocellulose membrane biosensors were demonstrated.



中文翻译:

基于纳米粒子的3D膜,用于阻抗式生物传感器应用。

本文报道了纳米ZnO / CuO和纳米ZnO硝酸纤维素膜生物传感器之间的比较,这两种传感器都是使用简单且廉价的超声技术制造的。为了生产纳米ZnO / CuO膜,该技术涉及超声处理1%(w / v)ZnO和1%(w / v)CuO纳米晶体胶体悬浮液,体积比为1:2。通过扫描电子显微镜和能量分散光谱法分析膜,其显示了纳米颗粒在膜中的梯度分布。阻抗谱表明,超声处理使输出信号增强了两倍以上。阻抗相位值的变化(频率为100 Hz)用于建立C反应蛋白(CRP)的剂量依赖性响应。

更新日期:2020-07-14
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