Purpose

Women with polycystic ovary syndrome (PCOS) have an increased ovarian responsiveness to exogenous recombinant follicle stimulating hormone (rFSH) but also have high rates of obesity, which is known to affect serum FSH concentrations following exogenous injection. The purpose of this study was to compare rFSH absorption and ovarian response between lean and overweight/obese PCOS subjects and normo-ovulatory controls.

Methods

Fourteen women with PCOS aged 18–42 years old with a BMI of 18.5–24.9 kg/m² (normal) or 25.0–40.0 kg/m² (overweight/obese) and eleven normo-ovulatory controls matched by age and BMI were included. After downregulation with oral contraceptives, participants were administered a single subcutaneous injection of 225 IU rFSH and underwent serial blood draws over 72 h.

Results

Lean PCOS subjects exhibited a significantly higher area under the curve (AUC) of baseline-corrected serum FSH over 72 h when compared with overweight/obese PCOS subjects (183.3 vs 139.8 IU*h/L, p = 0.0002), and lean, normo-ovulatory women had a significantly higher AUC FSH when compared with overweight/obese, normo-ovulatory women (193.3 vs 93.8 IU*h/L, p < 0.0001). Within overweight/obese subjects, those with PCOS had a significantly higher AUC FSH compared with normo-ovulatory controls (p = 0.0002). Lean PCOS subjects similarly had the highest AUC of baseline-corrected estradiol (6095 pg h/mL), compared with lean normo-ovulatory subjects (1931 pg h/mL, p < 0.0001) and overweight/obese PCOS subjects (2337 pg h/mL, p < 0.0001).

Conclusion

Lean PCOS subjects exhibited significantly higher baseline-corrected FSH and estradiol levels following rFSH injection compared with overweight/obese PCOS subjects with similar ovarian reserve markers. Amongst overweight/obese subjects, those with PCOS had significantly higher FSH and E2 levels when compared with normo-ovulatory controls.

中文翻译：

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多囊卵巢综合征和体重指数对重组人卵泡刺激素吸收的影响。

 目的

患有多囊卵巢综合征 (PCOS) 的女性卵巢对外源性重组卵泡刺激素 (rFSH) 的反应性增强，但肥胖率也很高，已知肥胖会影响外源性注射后的血清 FSH 浓度。本研究的目的是比较瘦和超重/肥胖 PCOS 受试者与正常排卵对照之间的 rFSH 吸收和卵巢反应。

 方法

纳入了 14 名 18-42 岁的 PCOS 女性，BMI 为 18.5-24.9 kg/m ² （正常）或 25.0-40.0 kg/m ² （超重/肥胖），以及 11 名年龄和 BMI 匹配的正常排卵对照者。 。口服避孕药下调后，参与者单次皮下注射 225 IU rFSH，并在 72 小时内进行连续抽血。

 结果

与超重/肥胖 PCOS 受试者相比，瘦 PCOS 受试者在 72 小时内表现出显着更高的基线校正血清 FSH 曲线下面积 (AUC)（183.3 vs 139.8 IU*h/L， p = 0.0002），而瘦、正常-与超重/肥胖、排卵正常的女性相比，排卵女性的 AUC FSH 显着更高（193.3 vs 93.8 IU*h/L， p < 0.0001）。在超重/肥胖受试者中，与正常排卵对照相比，PCOS 患者的 AUC FSH 显着更高 ( p = 0.0002)。与瘦的正常排卵受试者（1931 pg h/mL， p < 0.0001）和超重/肥胖的 PCOS 受试者（2337 pg h/mL）相比，瘦的 PCOS 受试者同样具有最高的基线校正雌二醇 AUC（6095 pg h/mL）。毫升， p < 0.0001）。

 结论

与具有相似卵巢储备标志物的超重/肥胖 PCOS 受试者相比，瘦 PCOS 受试者在注射 rFSH 后表现出显着更高的基线校正 FSH 和雌二醇水平。在超重/肥胖受试者中，与正常排卵对照相比，患有 PCOS 的受试者的 FSH 和 E2 水平显着较高。