Long non-coding RNAs (lncRNAs) have an established role in cell biology. Among their functions is the regulation of hematopoiesis. They characterize the different stages of hematopoiesis in a more lineage-restricted expression pattern than coding mRNAs. They affect hematopoietic stem cell renewal, proliferation, and differentiation of committed progenitors by interacting with master regulators transcription factors. Among these transcription factors, MYC has a prominent role. Similar to MYC’s transcriptional activation/amplification of protein coding genes, MYC also regulates lncRNAs’ expression profile, while it is also regulated by lncRNAs. Both myeloid and lymphoid malignancies are prone to the association of MYC with lncRNAs. Such interaction inhibits apoptosis, enhances cell proliferation, deregulates metabolism, and promotes genomic instability and resistance to treatment. In this review, we discuss the recent findings that encompass the crosstalk between lncRNAs and describe the pathways that very probably have a pathogenetic role in both acute and chronic hematologic malignancies.

长非编码RNA（lncRNA）在细胞生物学中已确立作用。它们的功能之一是调节造血功能。他们以比谱系mRNA更谱系限制的表达方式表征造血的不同阶段。它们通过与主调节因子转录因子相互作用，影响造血干细胞的更新，增殖和定型祖细胞的分化。在这些转录因子中，MYC具有重要作用。与MYC转录激活/扩增蛋白质编码基因相似，MYC还调节lncRNA的表达谱，同时也受lncRNA调节。髓样和淋巴样恶性肿瘤均易于MYC与lncRNA相关联。这种相互作用会抑制细胞凋亡，增强细胞增殖，破坏新陈代谢，并促进基因组不稳定和对治疗的抵抗力。在这篇综述中，我们讨论了涵盖lncRNA之间串扰的最新发现，并描述了可能在急性和慢性血液系统恶性肿瘤中均具有致病作用的途径。