Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD. Therefore, the inflammatory and anti-inflammatory cytokines, as well as their respective genes, have been proposed to play roles in pathophysiology of disease. This study has been conducted to elucidate the role of IL-2, IL-12, and IFN-γ single nucleotide polymorphisms (SNP) in this disease. Seventy-six patients who were diagnosed with IVDD and 140 healthy controls who complied with eligibility criteria were included. A total volume of 5 cc peripheral blood was obtained from each participant to investigate the IL-2 + 166G/T, IL-2 -330G/T, IL-12 − 1188A/C, and IFN-γ +847A/T SNPs through PCR-SSP method. The ‘TG’ and ‘TT’ genotypes of IL-2 − 330G/T polymorphism were significantly more common among patients and healthy controls respectively. The ‘GT’ and ‘TT’ haplotypes of IL-2 (comprised of -330G/T, and + 166G/T SNPs) were also more common among patients and controls respectively. This study indicated the significant role of IL-2 genotypes and haplotypes in IVDD. These SNPs were differently distributed in patients and controls. Therefore, alteration in the structure of IL-2 gene could play an important role in pathophysiology of IVDD.

中文翻译：

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白细胞介素2，白介素12和γ干扰素与伊朗人群椎间盘退变的关系。

椎间盘退变（IVDD）是一种与年龄相关的退行性疾病，表现为下腰痛或神经根痛。在IVDD的过程中，炎症会发生在椎间盘中。因此，已经提出了炎性和抗炎性细胞因子以及它们各自的基因在疾病的病理生理中起作用。进行了这项研究以阐明IL-2，IL-12和IFN-γ单核苷酸多态性（SNP）在该疾病中的作用。包括76名被诊断为IVDD的患者和140名符合入选标准的健康对照。从每个参与者中收集总体积为5 cc的外周血，以通过以下方法研究IL-2 + 166G / T，IL-2 -330G / T，IL-12 − 1188A / C和IFN-γ+ 847A / T SNP PCR-SSP方法。IL-2-330G / T多态性的“ TG”和“ TT”基因型分别在患者和健康对照组中更为普遍。IL-2的“ GT”和“ TT”单倍型（由-330G / T和+ 166G / T SNP组成）分别在患者和对照组中更为常见。这项研究表明IL-2基因型和单倍型在IVDD中的重要作用。这些SNP在患者和对照组中的分布不同。因此，IL-2基因结构的改变可能在IVDD的病理生理中起重要作用。这些SNP在患者和对照组中的分布不同。因此，IL-2基因结构的改变可能在IVDD的病理生理中起重要作用。这些SNP在患者和对照组中的分布不同。因此，IL-2基因结构的改变可能在IVDD的病理生理中起重要作用。