Abstract

We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOE ɛ4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. None of the models found evidence for associations between amyloid status and fasting glucose or HbA1c.

中文翻译：

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在患有痴呆症风险的健康个体中，外周胰岛素抵抗和其他2型糖尿病标志物与脑淀粉样蛋白沉积的关联。

摘要

我们在FINGER PET子研究的41名参与者中，通过PiB-PET扫描探索了2型糖尿病相关的血液标志物与脑淀粉样蛋白积累的关系。我们建立回归模型为葡萄糖和脂质代谢的大脑淀粉样状态with12血浆标志，糖尿病和控制APOE ɛ 4载状态。较低水平的胰岛素，胰岛素抵抗指数（HOMA-IR），C肽和纤溶酶原激活剂（PAI-1）与淀粉样蛋白阳性状态相关，尽管经多次测试调整后结果并不显着。这些模型均未发现淀粉样蛋白状态与空腹血糖或HbA1c之间存在关联的证据。