The available antiviral agents and their potential for the management of coronavirus disease 2019 (COVID-19) outbreak are important interventions. A systematic review and meta-analysis was performed to summarize the available evidence on the efficacy of nanoscale materials against coronaviruses in vitro and in animal models. PubMed, Scopus and Wiley Online Library databases were searched up to 4 March 2020. Studies that developed the efficacy of nanoscale materials against coronaviruses were included. Two reviewers independently extracted study characteristics and assessed risk of bias and applicability in the included studies. Meta-analyses were conducted to determine the overall inhibition efficacy of nanoscale materials against coronaviruses. A total of 21 studies were identified. Positive association was found between efficacy of nanoscale materials and coronaviruses in vitro and in animal models. The inhibition efficacy of nanoscale materials against coronavirus in vitro and in animal models were 1.84 (95% CI: 1.57, 2.15) and 1.66 (95% CI: 1.36, 2.02), respectively. Results of subgroup analysis of selected studies revealed that the nanoscale materials with spherical morphology were found to be more antiviral activity than the other morphologies against Middle East respiratory syndrome-coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). Using systematic review and meta-analysis, our results indicate that nanoscale materials are positive affect against coronaviruses. We might clarify the possible potential for the use of nanoscale materials for SARS-CoV-2.

中文翻译：

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纳米材料对冠状病毒-可能的SARS-CoV-2潜在抗病毒剂功效的系统评价和荟萃分析。

重要的干预措施包括可用的抗病毒药物及其对2019年冠状病毒疾病（COVID-19）爆发的控制潜力。进行了系统的综述和荟萃分析，以总结有关纳米材料对冠状病毒功效的现有证据。体外在动物模型中 检索截止到2020年3月4日的PubMed，Scopus和Wiley Online Library数据库。研究包括开发了纳米材料对抗冠状病毒的功效的研究。两名评价者独立提取研究特征并评估纳入研究的偏倚风险和适用性。进行荟萃分析，以确定纳米材料对冠状病毒的总体抑制作用。总共鉴定了21个研究。发现纳米材料的功效与冠状病毒之间存在正相关体外在动物模型中 纳米材料对冠状病毒的抑制作用体外在动物模型中，分别为1.84（95％CI：1.57、2.15）和1.66（95％CI：1.36、2.02）。选定研究的亚组分析结果表明，球形结构的纳米级材料对中东呼吸综合征冠状病毒（MERS-CoV）和严重急性呼吸综合征冠状病毒（SARS-CoV）的抗病毒活性高于其他形态。使用系统评价和荟萃分析，我们的结果表明，纳米级材料对冠状病毒具有积极影响。我们可能会阐明将纳米级材料用于SARS-CoV-2的潜在潜力。