Competitive milling was successfully employed to determine the relative affinity of copper(II) ions towards selected L-amino acids (Asn, Gln, His, Phe, Pro, and Trp). Although Cu(II) ions readily form complexes with all the investigated acids, only L-Trp is selectively bound from its solid (binary) mixtures [in the form of Cu(Trp)₂]. For the investigated reactions, solid-state milling proved to be superior to solution-based methods as it avoids unwanted competition and solubility problems while opening a simple route towards ternary coordination compounds (otherwise hard to obtain from solution).

中文翻译：

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固态中铜（II）离子对L-氨基酸的亲和力：形成混合配合物的简单途径

有竞争力的铣削被成功用于确定铜的相对亲和力（II）向所选择的离子大号α-氨基酸（天冬酰胺，谷氨酰胺，他，苯丙氨酸，Pro的，和色氨酸）。尽管Cu（II）离子很容易与所有研究的酸形成络合物，但只有L - Trp从其固体（二元）混合物中以[Cu（Trp）₂的形式选择性结合]。对于所研究的反应，固态研磨被证明优于基于溶液的方法，因为它避免了不必要的竞争和溶解性问题，同时为三元配位化合物开辟了一条简单的途径（否则很难从溶液中获得）。