Homogeneous cobalt-catalyzed deoxygenative hydrogenation of amides to amines,Catalysis Science & Technology

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Homogeneous cobalt-catalyzed deoxygenative hydrogenation of amides to amines
Catalysis Science & Technology ( IF 4.4 ) Pub Date : 2020-07-03 , DOI: 10.1039/d0cy01078b
Veronica Papa _{1,

2,

3} , Jose R. Cabrero-Antonino _{1,

2,

3,

4,

5} , Anke Spannenberg _{1,

2,

3} , Kathrin Junge _{1,

2,

3} , Matthias Beller _{1,

2,

3}

Affiliation

The first general and efficient cobalt-catalyzed deoxygenative hydrogenation of amides to amines is presented. The optimal catalytic system based on a combination of [Co(NTf₂)₂] and (p-anisyl)triphos (L3) in the presence of [Me₃SiOTf] as acidic co-catalyst facilitates the direct hydrogenation of a broad range of amides to the corresponding amines under mild conditions. A set of control experiments indicate that, after the initial reduction of the amide carboxylic group to the well-known hemiaminal intermediate, the reaction mainly proceeds through C–O bond cleavage though other pathways might be also involved to a minor extent.

中文翻译：

钴的均相钴催化脱氧加氢为胺

介绍了酰胺的第一个常规且有效的钴催化脱氧加氢为胺。在[Me ₃ SiOTf]作为酸性助催化剂的情况下，基于[Co（NTf ₂）₂ ]和（对-茴香基）_三磷（L3）的组合的最佳催化体系有利于广泛范围内的直接氢化。酰胺在温和的条件下转化为相应的胺。一组对照实验表明，在酰胺羧基最初还原为众所周知的半胱氨酸中间体后，反应主要通过C–O键断裂进行，尽管其他途径可能也有少量参与。

更新日期：2020-07-03

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