Accumulating evidence so far has shown that EBV’s miRNAs have been found to be involved in cancer progression. However, the comprehensive EBV miRNA expression profiles and their biological significance in EBV-associated diseases are not well documented. A comprehensive profiling of EBV-encoded miRNAs expressed in CAEBV, EBV-HLH, and nasopharyngeal carcinoma (NPC) patients was constructed, and the results showed that miR-BART19-3p was upregulated in all these diseases. Ectopic expression of miR-BART19-3p induced EBV-negative cell proliferation and suppressed cell apoptosis. Molecularly, adenomatous polyposis coli (APC) was identified to be a direct target of miR-BART19-3p, and APC mRNA expression was inversely correlated with miR-BART19-3p in CAEBV samples. Our results demonstrated that miR-BART19-3p contributes to the tumorigenesis of EBV-associated diseases and may be a potential therapeutic target.

中文翻译：

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miR-BART19-3p在爱泼斯坦-巴尔病毒相关疾病中的致癌作用。

迄今为止，越来越多的证据表明，EBV的miRNA已被发现与癌症的发展有关。但是，关于EBV miRNA的全面表达谱及其在EBV相关疾病中的生物学意义尚未得到很好的证明。构建了在CAEBV，EBV-HLH和鼻咽癌（NPC）患者中表达的EBV编码的miRNA的综合概况，结果表明，在所有这些疾病中，miR-BART19-3p均被上调。miR-BART19-3p的异位表达诱导EBV阴性细胞增殖并抑制细胞凋亡。在分子上，腺瘤性息肉病（APC）被确定为miR-BART19-3p的直接靶标，并且CAEBV样品中APC mRNA表达与miR-BART19-3p呈负相关。