Introduction

The incidence rate of MS is a valuable indicator of the recent changes in the risk of this disease, and it is widely implicated for health planning purposes.

Objectives

This study aims to determine the MS incidence over the past eleven years in Mazandaran province and to compare it with the other parts of Iran and the world.

Materials and methods

This retrospective study is conducted in Mazandaran province by using registered data in the files of the patients with their consent. The yearly crude incidence rates, age, and sex-specific incidence rates and directly standardized incidence rates of this population are calculated, and the temporal changes in the incidence rates are analyzed.

Results

662 (26%) male patients with the mean (SD) age of 32.6 (9.48) and 1884 (74%) female patients with the mean (SD) age of 31.9 (9.15) are studied. The direct standardized incidence rate of MS was 3.28 in 100.000 in 2008 and reached 4.17 in 100.000 in 2018, and this increase was significant (p<0.05). Also, the yearly prevalence of MS increased from 24.4 to 72.5 in this period.

Conclusions

The MS incidence has increased in Mazandaran. The potential role of some genetic or environmental factors needs further investigation.

中文翻译：

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伊朗Mazandaran省的年龄和性别调整后的多发性硬化症（MS）发病率和年流行率：一项为期11年的研究。

介绍

MS的发生率是该疾病风险最近变化的重要指标，广泛用于健康计划目的。

目标

这项研究旨在确定过去11年中Mazandaran省的MS发病率，并将其与伊朗其他地区和世界进行比较。

材料和方法

这项回顾性研究是在马赞达兰省通过征得患者同意的患者档案中的注册数据进行的。计算该人群的年度粗略发病率，年龄和特定性别的发病率以及直接标准化的发病率，并分析发病率的时间变化。

结果

研究了662名（26％）平均（SD）年龄为32.6岁（9.48）的男性患者和1884名（74％）平均（SD）年龄为31.9岁（9.15）的女性患者。MS的直接标准化发病率在2008年为每100.000中3.28，而在2018年为100.000中的4.17，这一增加是显着的（p <0.05）。此外，在此期间，MS的年患病率从24.4增加到72.5。

结论

Mazandaran地区的MS发病率有所上升。一些遗传或环境因素的潜在作用需要进一步研究。