Psychiatric disorders are highly prevalent and display considerable clinical and genetic overlap. Dopaminergic and serotonergic neurotransmission have been shown to have an important role in many psychiatric disorders. Here we aim to assess the genetic contribution of these systems to eight psychiatric disorders (ADHD, ANO, ASD, BIP, MD, OCD, SCZ and TS) using publicly available GWAS analyses performed by the Psychiatric Genomics Consortium. To do so, we elaborated four different gene sets using the Gene Ontology and KEGG pathways tools: two "wide" selections for dopamine (DA) and for serotonin (SERT), and two "core" selections for the same systems. At the gene level, we found 67 genes from the DA and/or SERT gene sets significantly associated with one of the studied disorders, and 12 of them were associated with two different disorders. Gene-set analysis revealed significant associations for ADHD and ASD with the wide DA gene set, for BIP with the wide SERT gene set, and for MD with both the core DA set and the core SERT set. Interestingly, interrogation of the cross-disorder GWAS meta-analysis displayed association with the wide DA gene set. To our knowledge, this is the first time that these two neurotransmitter systems have systematically been inspected in these disorders. Our results support a cross-disorder contribution of dopaminergic and serotonergic systems in several psychiatric conditions.

中文翻译：

---

多巴胺能和血清素能途径对精神疾病的遗传贡献的综合探索

精神疾病高度流行，并且表现出相当大的临床和遗传重叠。多巴胺能和血清素能神经传递已被证明在许多精神疾病中具有重要作用。在这里，我们旨在利用精神基因组学协会进行的公开可用的GWAS分析评估这些系统对八种精神疾病（ADHD，ANO，ASD，BIP，MD，OCD，SCZ和TS）的遗传贡献。为此，我们使用Gene Ontology和KEGG途径工具精心设计了四种不同的基因集：针对多巴胺（DA）和5-羟色胺（SERT）的两个“广泛”选择，以及针对同一系统的两个“核心”选择。在基因水平上，我们发现来自DA和/或SERT基因组的67个基因与所研究的疾病之一显着相关，其中有12种与两种不同的疾病有关。基因集分析显示，ADHD和ASD与宽DA基因集，BIP与宽SERT基因集，MD与核心DA集和核心SERT集都有显着关联。有趣的是，对跨境GWAS荟萃分析的询问显示与广泛的DA基因集相关。据我们所知，这是首次在这两种疾病中系统检查这两种神经递质系统。我们的研究结果支持了多种精神病学条件下多巴胺能和血清素能系统的跨领域贡献。跨境GWAS荟萃分析的询问显示与广泛的DA基因组相关。据我们所知，这是首次在这两种疾病中系统检查这两种神经递质系统。我们的研究结果支持了多种精神病学条件下多巴胺能和血清素能系统的跨领域贡献。跨境GWAS荟萃分析的询问显示与广泛的DA基因组相关。据我们所知，这是首次在这两种疾病中系统检查这两种神经递质系统。我们的研究结果支持了多种精神病学条件下多巴胺能和血清素能系统的跨领域贡献。