Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. Here, we report that low plasma interleukin-3 (IL-3) levels were associated with increased severity and mortality during SARS-CoV-2 infections. IL-3 promoted the recruitment of antiviral circulating plasmacytoid dendritic cells (pDCs) into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells. This study identifies IL-3 as a predictive disease marker and potential therapeutic target for SARS-CoV-2 infections.

中文翻译：

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白介素3是SARS-CoV-2感染期间严重程度和预后的预测指标

严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）是全球性的健康威胁。在这里，我们报告说低血浆白细胞介素3（IL-3）水平与SARS-CoV-2感染期间的严重程度和死亡率增加相关。IL-3通过刺激肺CD123 +上皮细胞的CXCL12分泌，促进抗病毒循环浆细胞样树突状细胞（pDC）募集入气道。这项研究确定IL-3是SARS-CoV-2感染的预测性疾病标志物和潜在治疗靶标。