Chemical and Toxicological Characterization of Vaping Emission Products from Commonly Used Vape Juice Diluents.,Chemical Research in Toxicology

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Chemical and Toxicological Characterization of Vaping Emission Products from Commonly Used Vape Juice Diluents.
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2020-07-03 , DOI: 10.1021/acs.chemrestox.0c00174
Huanhuan Jiang _{1,

2} , C M Sabbir Ahmed ₃ , Thomas J Martin ₄ , Alexa Canchola ₃ , Iain W H Oswald ₄ , Jose Andres Garcia ₂ , Jin Y Chen ₃ , Kevin A Koby ₄ , Anthony J Buchanan ₅ , Zixu Zhao ₆ , Haofei Zhang ₆ , Kunpeng Chen ₁ , Ying-Hsuan Lin _{1,

3}

Affiliation

Recent reports have linked severe lung injuries and deaths to the use of e-cigarettes and vaping products. Nevertheless, the causal relationship between exposure to vaping emissions and the observed health outcomes remains to be elucidated. Through chemical and toxicological characterization of vaping emission products, this study demonstrates that during vaping processes, changes in chemical composition of several commonly used vape juice diluents (also known as cutting agents) lead to the formation of toxic byproducts, including quinones, carbonyls, esters, and alkyl alcohols. The resulting vaping emission condensates cause inhibited cell proliferation and enhanced cytotoxicity in human airway epithelial cells. Notably, substantial formation of the duroquinone and durohydroquinone redox couple was observed in the vaping emissions from vitamin E acetate, which may be linked to acute oxidative stress and lung injuries reported by previous studies. These findings provide an improved molecular understanding and highlight the significant role of toxic byproducts in vaping-associated health effects.

中文翻译：

来自常用 Vape 果汁稀释剂的 Vaping 排放产物的化学和毒理学表征。

最近的报告将严重的肺损伤和死亡与电子烟和电子烟产品的使用联系起来。然而，暴露于电子烟排放物与观察到的健康结果之间的因果关系仍有待阐明。通过对电子烟排放产品的化学和毒理学表征，本研究表明，在电子烟过程中，几种常用电子烟汁稀释剂（也称为切割剂）的化学成分发生变化会导致形成有毒副产物，包括醌类、羰基化合物、酯类, 和烷基醇。由此产生的电子烟排放冷凝物会抑制人气道上皮细胞的细胞增殖并增强细胞毒性。尤其，在维生素 E 醋酸盐的电子烟排放中观察到了杜罗醌和杜罗氢醌氧化还原对的大量形成，这可能与之前研究报告的急性氧化应激和肺损伤有关。这些发现提供了更好的分子理解，并强调了有毒副产品在与电子烟相关的健康影响中的重要作用。

更新日期：2020-08-17

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