Remotely Triggered Liquefaction of Hydrogel Materials.,ACS Nano

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Remotely Triggered Liquefaction of Hydrogel Materials.
ACS Nano ( IF 15.8 ) Pub Date : 2020-07-02 , DOI: 10.1021/acsnano.0c04522
Søren L Pedersen ₁ , Tin H Huynh ₁ , Philipp Pöschko ₁ , Anne Sofie Fruergaard ₁ , Morten T Jarlstad Olesen ₁ , Yaqing Chen _{1,

2} , Henrik Birkedal _{1,

2} , Guruprakash Subbiahdoss ₃ , Erik Reimhult ₃ , Jan Thøgersen ₁ , Alexander N Zelikin _{1,

2}

Affiliation

Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. In this work, we engineer triggered liquefaction of hydrogel biomaterials in response to internal, localized heating, mediated by near-infrared light as external stimulus. This adaptable behavior is engineered into the readily available physical hydrogels based on poly(vinyl alcohol), using gold nanoparticles or an organic photothermal dye as heat generators. Upon laser light irradiation, engineered biomaterials underwent liquefaction within seconds. Pulsed laser light irradiation afforded controlled, on-demand release of the incorporated cargo, successful for small molecules as well as proteins (enzymes) in their biofunctional form.

中文翻译：

水凝胶材料的远程触发液化。

诸如触发崩解之类的适应性行为为（生物）材料在材料科学和工程学的各种应用中提供了广泛的范围和实用性。由于越来越多的环境因素以及在医疗实践中越来越多地使用植入物，这种材料的影响持续增长。但是，这种材料的例子仍然很少。在这项工作中，我们设计工程师响应内部的局部加热（由近红外光作为外部刺激介导），触发了水凝胶生物材料的液化。使用金纳米颗粒或有机光热染料作为生热剂，将这种适应性行为设计到了基于聚乙烯醇的随时可用的物理水凝胶中。在激光照射下，工程生物材料会在几秒钟内发生液化。

更新日期：2020-07-28

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