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Efficient weighted univariate clustering maps outstanding dysregulated genomic zones in human cancers.
Bioinformatics ( IF 4.4 ) Pub Date : 2020-07-03 , DOI: 10.1093/bioinformatics/btaa613
Mingzhou Song 1, 2 , Hua Zhong 1
Affiliation  

Chromosomal patterning of gene expression in cancer can arise from aneuploidy, genome disorganization, or abnormal DNA methylation. To map such patterns, we introduce a weighted univariate clustering algorithm to guarantee linear runtime, optimality, and reproducibility.

中文翻译:

有效的加权单变量聚类图可绘制出人类癌症中突出的失调的基因组区域。

癌症中基因表达的染色体模式可能来自非整倍性,基因组混乱或异常的DNA甲基化。为了映射这种模式,我们引入了加权单变量聚类算法以确保线性运行时间,最优性和可重复性。
更新日期:2020-07-03
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