Tissue elongation is a necessary process in metazoans to implement their body plans that is not fully understood. Here we propose a mechanism based on the interplay between cellular mechanics and primordia patterning that results in self-sustained planar intercalations. Thus, we show that a location-dependent modulation of the mechanical properties of cells leads to robust axis extension. To illustrate the plausibility of this mechanism, we test it against different patterning models by means of computer simulations of tissues where we implemented mechano-signaling feedbacks. Our results suggest that robust elongation relies on a trade-off between cellular and tissue strains that is orchestrated through the cleavage orientation. In the particular context of axis extension in Turing-patterned tissues, we report that different directional cell activities cooperate synergetically to achieve elongation. Altogether, our findings help to understand how the axis extension phenomenon emerges from the dynamics of individual cells.

组织伸长是后生动物实施其身体计划的必要过程，目前尚不完全清楚。在这里，我们提出了一种基于细胞力学与原基构图之间相互作用的机制，该机制导致了自我维持的平面嵌入。因此，我们表明细胞的机械性能的位置依赖的调制导致健壮的轴延伸。为了说明这种机制的合理性，我们通过对组织进行计算机信号模拟的计算机模拟，针对不同的图案化模型对其进行了测试。我们的结果表明，稳健的延伸依赖于通过裂解方向精心安排的细胞和组织菌株之间的权衡。在图灵图案组织中轴延伸的特定情况下，我们报告说不同方向的细胞活动协同合作以实现伸长。总而言之，我们的发现有助于理解轴延伸现象是如何从单个细胞的动力学中出现的。