Recent evidence showing degeneration of the noradrenergic system in the locus coeruleus (LC) in Alzheimer’s disease (AD) has motivated great interest in noradrenaline (NA) as a potential brain hallmark of the disease. Despite the current exploration of blood markers for AD, the deregulation of the plasma NA concentration ([NA]_plasma) in AD is currently not well understood. This retrospective study includes a cohort of 71 patients (32 AD patients, 22 with other dementia and 17 without dementia) who were given consultations for memory complaints in the Cognitive Neurology Center of Lariboisière (Paris) between 2009 and 2014. As previously described in brain tissue, we show for the first time a linear correlation between [NA]_plasma and Mini Mental State Examination (MMSE) score in AD patients. We observed that high [NA]_plasma in AD patients was associated with higher [Aβ_1–42]_CSF than in other AD patients with [NA]_plasma similar to NC patients. In parallel, we observed a lower (p-Tau/Tau)_CSF in AD patients with low [NA]_plasma than in non-AD patients with [NA]_plasma similar to [NA]_plasma in NC patients. Our data suggest that [NA]_plasma could be a potential biomarker of disease evolution in the context of AD and could possibly improve early diagnosis.

最近的证据显示，阿尔茨海默氏病（AD）的蓝斑能量（LC）中去甲肾上腺素能系统的退化引起了人们对去甲肾上腺素（NA）作为该病潜在的脑标志的极大兴趣。尽管血液标志物的AD的当前勘探，等离子体NA浓度的失调（[NA]_等离子体在AD）是目前不是很了解。这项回顾性研究包括2009年至2014年间在Lariboisière（巴黎）认知神经病学中心接受记忆障碍咨询的71例患者（32例AD患者，22例其他痴呆患者和17例无痴呆患者）。组织，我们首次展示了[NA]_血浆之间的线性相关性和AD患者的迷你精神状态检查（MMSE）得分。我们观察到，与其他与NC患者相似的[NA]_血浆的AD患者相比，AD患者的高[NA]_血浆与较高的[ _Aβ1–42 ] _CSF相关。同时，我们观察到[NA]_血浆水平较低的AD患者的_CSF（p-Tau / Tau）低于NC患者的[NA]_血浆水平与[NA]_血浆相似的非AD患者。我们的数据表明[NA]_血浆可能是AD背景下疾病发展的潜在生物标志物，并可能改善早期诊断。