Cholinergic systems modulate dopaminergic function in brain pathways are thought to mediate heroin addiction. This study investigated whether huperzine A, an acetylcholinesterase inhibitor, has beneficial effects on heroin reward and heroin-seeking behavior. Rats were trained to self-administer heroin (50 μg/kg/infusion) under the fixed ratio 1 schedule for 14 days and then drug-seeking was extinguished for 10 days, after which reinstatement of drug-seeking was induced by conditioned cues or heroin priming. Acute treatment with huperzine A at dose from 0.05 to 0.2 mg/kg potently and dose-dependently suppressed the cue- and heroin-induced reinstatement of heroin-seeking behavior following extinction. Huperzine A at these doses failed to alter either heroin rewarding effect or spontaneous locomotion activity. The study demonstrated that acute treatment with huperzine A inhibited heroin-seeking behavior, suggesting that huperzine A may be used as an adjuvant treatment for heroin relapse and addiction.

中文翻译：

---

石杉碱 A 抑制由线索或海洛因引发的大鼠海洛因寻求行为。

胆碱能系统调节大脑通路中的多巴胺能功能被认为介导海洛因成瘾。这项研究调查了石杉碱甲，一种乙酰胆碱酯酶抑制剂，是否对海洛因奖赏和海洛因寻求行为有有益影响。训练大鼠在固定比例 1 计划下自我给药海洛因（50 μg/kg/输液），持续 14 天，然后戒毒 10 天，之后通过条件线索或海洛因诱导重新开始吸毒启动。用 0.05 至 0.2 mg/kg 剂量的石杉碱 A 进行急性治疗，有效且剂量依赖性地抑制了线索和海洛因诱导的灭绝后海洛因寻求行为的恢复。这些剂量的石杉碱 A 未能改变海洛因奖赏效应或自发运动活动。