Purpose: Age-related macular degeneration (AMD) as the leading cause of central visual loss in the developed countries has extensive pathologic similarities with Alzheimer’s disease (AD). Saitohin rs62063857 Q7 R polymorphism is associated with increased risk of AD though we decided to evaluate the possible association of this polymorphism with advanced AMD.

Materials and Methods: 152 advanced AMD patients (134 wet AMD and 18 geographic atrophy) and 75 healthy controls included in this study. Cases and controls went through a standard ophthalmologic examination by a retinal specialist. Saitohin gene rs62063857 polymorphism determined by using PCR technique and restriction enzyme HinFI. To evaluate the differences between groups we used t-test, Chi-Squared and one-tailed Fisher exact test.

Results: Distribution of genotypes was not significantly different between total AMD or wet AMD patients compared to that of controls (total AMD RR+QR: OR = 1.51, CI = 0.82–2.79, P = .12; wet AMD RR+QR: OR = 1.39, CI = 0.74–2.59, P = .19). The RR+QR genotypes were significantly higher in dry AMD group compared to that of controls (RR+QR: OR = 2.75, CI = 0.96–7.9, P = .05).

Conclusion: Our results showed that although STH Q7 R polymorphism was not associated with wet AMD susceptibility it was significantly associated with geographic atrophy.

目的：与年龄相关的黄斑变性（AMD）是发达国家中枢性视力丧失的主要原因，与阿尔茨海默氏病（AD）具有广泛的病理相似性。尽管我们决定评估这种多态性与晚期AMD的可能关联，但Saitohin rs62063857 Q7 R多态性与AD风险增加相关。

材料和方法：这项研究包括152名晚期AMD患者（134名湿性AMD和18名地理萎缩）和75名健康对照。病例和对照由视网膜专家进行了标准的眼科检查。使用PCR技术和限制性内切酶HinFI确定了斋藤基因rs62063857多态性。为了评估组之间的差异，我们使用了t检验，卡方检验和单尾Fisher精确检验。

结果：总AMD或湿性AMD患者的基因型分布与对照组相比无显着差异（总AMD RR + QR：OR = 1.51，CI = 0.82–2.79，P = .12；湿性AMD RR + QR：OR = 1.39，CI = 0.74-2.59，P = .19）。与对照组相比，干AMD组的RR + QR基因型显着更高（RR + QR：OR = 2.75，CI = 0.96-7.9，P = 0.05）。

结论：我们的结果表明，尽管STH Q7 R多态性与湿性AMD易感性无关，但与地理萎缩显着相关。