Abstract

Spherical microspheres of methotrexate intercalated layered double hydroxides (MTX/LDHs) have been synthesized by the calcination-reconstruction method and using the carbon spheres as template. Here, the effect of carbon spheres’ size on the morphology, drug-loading capacity and controlled-release property of the final product-MTX/LDHs nanohybrids are examined in details. It has been found out that the morphology of MTX/LDHs nanohybrids synthesized without template is irregular and aggregated seriously, while the MTX/LDHs nanohybrids prepared with the template of carbon spheres are spherical and monodispersed. With increasing in the size of carbon spheres, the particle size of MTX/LDHs is increasing gradually, and the morphology changes from irregular to the regular one. A set of characterization technologies including Zeta potentials, sustained-release performance and anticancer effect will be carried out to investigate the physical and chemical properties, and it’s indicated that spherical MTX/LDHs have excellent controlled-release property and good anticancer effect. Therefore, this work provides a promising approach for the design and synthesis of spherical MTX/LDHs nanohybrids, which can be potentially applied in drug delivery devices.

摘要

以碳球为模板，采用煅烧-重构法合成了甲氨蝶呤插层层状双氢氧化物（MTX/LDHs）球形微球。在这里，详细研究了碳球尺寸对最终产品-MTX/LDHs 纳米杂化物的形态、载药量和控释性能的影响。发现无模板合成的MTX/LDHs纳米杂化物形貌不规则且聚集严重，而以碳球为模板制备的MTX/LDHs纳米杂化物呈球形且单分散。随着碳球尺寸的增加，MTX/LDHs的粒径逐渐增大，形态由不规则变为规则。一套表征技术，包括 Zeta 电位，将对其缓释性能和抗癌作用进行理化性质研究，表明球形MTX/LDHs具有优异的控释性和良好的抗癌作用。因此，这项工作为球形 MTX/LDHs 纳米杂化物的设计和合成提供了一种很有前景的方法，该方法可潜在地应用于药物输送装置。