Context: In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine.Objective: This clinical trial was performed to determine whether the use of the 'ward' vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. (Myrtaceae) and Nardostachys jatamansi (D.Don) DC. (Caprifoliaceae) could alleviate the symptoms of vulvovaginal candidiasis.Materials and methods: A parallel double-blinded placebo-controlled study was done. Eighteen to fifty-year-old women with vulvovaginal candidiasis were divided into the 'ward' and placebo groups, 46 individuals in each group. The 'ward' group received the 'ward' vaginal tablet containing 200 mg of dried extract. Placebo group received a placebo (composed of corn starch and lactose). One tablet was applied through the vagina for 7 consecutive nights.Results: Two weeks after medication administration, the vaginal discharge sample of patients was re-cultured; 29 patients (63.045%) in the 'ward' group and 6 (13.04%) patients in the placebo group had negative culture (p < 0.001). All clinical symptoms including itching, irritation, and vaginal discharge were significantly reduced in the 'ward' group compared with the placebo group following the intervention and the follow up (p < 0.05).Discussion and conclusions: The findings suggest the 'ward' vaginal tablet could ameliorate vulvovaginal candidiasis. Future larger studies are recommended due to compare the therapeutic effect of the 'ward' vaginal tablet with common treatments.

中文翻译：

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阴道片剂作为波斯药物治疗外阴阴道念珠菌病的功效：一项双盲、随机、安慰剂对照试验

背景：在波斯医学中，外用成分，如大马士革玫瑰（Rosa damascena Mill）。（蔷薇科），通常被推荐用于治疗子宫疾病。对这些历史文献的科学评估对于发现传统医学中新的潜在用途很有价值。 目的：进行这项临床试验是为了确定是否使用含有大马士革蔷薇 (Rosa damascena, Punica granatum L. (Punicaceae)) 的“病房”阴道药片, Querqus infectoria Oliv。（壳斗科）、桃金娘科（Myrtaceae）和 Nardostachys jatamansi (D.Don) DC。（忍冬科）可以减轻外阴阴道念珠菌病的症状。 材料和方法：进行了平行双盲安慰剂对照研究。十八至五十岁患有外阴阴道念珠菌病的女性被分为“病房”和安慰剂组，每组46人。“病房”组接受含有 200 毫克干提取物的“病房”阴道片。安慰剂组接受安慰剂（由玉米淀粉和乳糖组成）。连续7晚经阴道给药1片。结果：给药2周后，患者阴道分泌物标本复培养；“病房”组 29 名患者 (63.045%) 和安慰剂组 6 名 (13.04%) 患者培养阴性（p < 0.001）。在干预和随访后，与安慰剂组相比，“病房”组的所有临床症状（包括瘙痒、刺激和阴道分泌物）均显着减少（p < 0.05）。 讨论和结论：研究结果表明“病房” 阴道片可改善外阴阴道念珠菌病。由于比较“病房”阴道片与常见治疗方法的治疗效果，建议未来进行更大规模的研究。