Abstract

Three anthraquinone analogues (1–3) were isolated by phytochemical work on EtOAc-soluble ingredients extracted from the roots of Polygonatum odoratum. The structures of all isolates were elucidated by NMR, MS and CD experiments, of which 1 (polygodoquinone A) was identified as a new anthraquinone derivative. Specifically, 1 represents an unusual structure composed of a naphthoquinone derivative linked to an anthraquinone via a C-C bond. 1–3 exhibited remarkable influenza A virus inhibitory activity with IC₅₀ values of 11.4, 11.0, and 2.3 μM, respectively, which were better than ribavirin as the positive control.

中文翻译：

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具有抑制黄精甲型流感病毒活性的蒽醌类似物

摘要

三个蒽醌类似物（1 - 3）通过植物化学物质工作从根部EtOAc萃取可溶成分分离玉竹。所有分离物的结构均通过NMR、MS和CD实验阐明，其中1 (polygodoquinone A)被鉴定为新的蒽醌衍生物。具体来说，1表示一种不寻常的结构，由萘醌衍生物通过 CC 键与蒽醌连接而成。1 - 3表现出显着的A型流感病毒的抑制活性与IC _50个11.4，11.0，和2.3μM，分别，高于利巴韦林作为阳性对照更好的值。