ABSTRACT

Household air pollution is a leading risk factor for morbidity and premature mortality. Numerous cookstoves have been developed to reduce household air pollution, but it is unclear whether such cookstoves meaningfully improve health. In a controlled exposure study with a crossover design, we assessed the effect of pollution emitted from multiple cookstoves on acute differences in blood lipids and inflammatory biomarkers. Participants (n = 48) were assigned to treatment sequences of exposure to air pollution emitted from five cookstoves and a filtered-air control. Blood lipids and inflammatory biomarkers were measured before and 0, 3, and 24 hours after treatments. Many of the measured outcomes had inconsistent results. However, compared to control, intercellular adhesion molecule-1 was higher 3 hours after all treatments, and C-reactive protein and serum amyloid-A were higher 24 hours after the highest treatment. Our results suggest that short-term exposure to cookstove air pollution can increase inflammatory biomarkers within 24 hours.

摘要

家庭空气污染是发病率和过早死亡的主要风险因素。已经开发出许多炉灶来减少家庭空气污染，但尚不清楚此类炉灶是否能显着改善健康状况。在一项采用交叉设计的受控暴露研究中，我们评估了多个炉灶排放的污染对血脂和炎症生物标志物的急性差异的影响。参与者 (n = 48) 被分配到暴露于五个炉灶和过滤空气控制装置排放的空气污染的处理序列。在治疗前和治疗后 0、3 和 24 小时测量血脂和炎症生物标志物。许多测量结果的结果不一致。然而，与对照相比，细胞间粘附分子-1在所有处理后3小时均较高，C-反应蛋白和血清淀粉样蛋白-A 在最高治疗后 24 小时更高。我们的结果表明，短期接触炉灶空气污染会在 24 小时内增加炎症生物标志物。