Candida haemulonii is a complex formed by C. haemulonii sensu stricto, C. haemulonii var. vulnera, and C. duobushaemulonii. Members of this complex are opportunistic pathogens closely related to C. pseudohaemulonii, C. lusitaniae, and C. auris, all members of a multidrug-resistant clade. Complete genome sequences for all members of this group are available in the GenBank database, except for C. haemulonii var. vulnera. Here, we report the first draft genomes of two C. haemulonii var. vulnera (isolates K1 and K2) and comparative genome analysis of closely related fungal species. The isolates were biofilm producers and non-susceptible to amphotericin B and fluconazole. The draft genomes comprised 350 and 387 contigs and total genome sizes of 13.21 and 13.26 Mb, with 5,479 and 5,507 protein-coding genes, respectively, allowing the identification of virulence and resistance genes. Comparative analyses of orthologous genes within the multidrug-resistant clade showed a total of 4,015 core clusters, supporting the conservation of 24,654 proteins and 3,849 single-copy gene clusters. Candida haemulonii var. vulnera shared a larger number of clusters with C. haemulonii and C. auris; however, more singletons were identified in C. lusitaniae and C. auris. Additionally, a multiple sequence alignment of Erg11p proteins revealed variants likely involved in reduced susceptibility to azole and polyene antifungal agents. The data presented in this work will, therefore, be of utmost importance for researchers studying the biology of the C. haemulonii complex and related species.

假丝酵母 是由 严密梭状芽胞杆菌， 哈密​​瓜 变种 vulnera和 C. duobushaemulonii。该复合物的成员是与之密切相关的机会性病原体假梭菌， 卢梭菌和 金龟子，是耐多药进化枝的所有成员。GenBank数据库中提供了该组所有成员的完整基因组序列，除了哈密​​瓜 变种 vulnera。在这里，我们报告了两个基因组的初稿哈密​​瓜 变种 vulnera（分离K1和K2）和比较相关的真菌物种的比较基因组分析。分离物是生物膜生产者，对两性霉素B和氟康唑不敏感。基因组草图包含350和387个重叠群，总基因组大小为13.21和13.26 Mb，分别具有5479和5507个蛋白质编码基因，可以鉴定毒力和抗性基因。耐多药进化枝中直系同源基因的比较分析显示，共有4,015个核心簇，支持保存24,654个蛋白质和3,849个单拷贝基因簇。假丝酵母 变种 vulnera 与更多的集群共享 哈密​​瓜 和 金龟子; 但是，在卢梭菌 和 金龟子。此外，Erg11p蛋白的多序列比对揭示了可能参与降低对唑和多烯抗真菌剂敏感性的变异体。因此，这项工作中提供的数据对于研究动物生物学的研究人员将至关重要。哈密​​瓜 复杂和相关物种。