Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease,Journal of Neurochemistry

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Diagnostic and therapeutic potential of exosomes in Alzheimer’s disease
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2020-07-03 , DOI: 10.1111/jnc.15112
Tânia Soares Martins ₁ , Dário Trindade ₁ , Margarida Vaz ₁ , Inês Campelo ₂ , Martim Almeida ₂ , Guilherme Trigo ₂ , Odete A B da Cruz E Silva _{1,

3} , Ana Gabriela Henriques ₁

Affiliation

Exosomes are small extracellular vesicles released by almost all cell types in physiological and pathological conditions. The exosomal potential to unravel disease mechanisms, or to be used as a source of biomarkers, is being explored, in particularly in the field of neurodegenerative diseases. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world and exosomes appear to have a relevant role in disease pathogenesis. This review summarizes the current knowledge on exosome contributions to AD as well as their use as disease biomarker resources or therapeutic targets. The most recent findings with respect to both protein and miRNA biomarker candidates for AD, herein described, highlight the state of the art in this field and encourage the use of exosomes derived from biofluids in clinical practice in the near future.

中文翻译：

外泌体在阿尔茨海默氏病中的诊断和治疗潜力

外泌体是在生理和病理条件下几乎所有细胞类型释放的小细胞外囊泡。尤其在神经退行性疾病领域，正在探索揭示疾病机制或被用作生物标记物来源的外泌体潜力。阿尔茨海默氏病（AD）是世界上最普遍的神经退行性疾病，外泌体似乎在疾病发病机理中具有相关作用。这篇综述总结了外泌体对AD的贡献及其作为疾病生物标志物资源或治疗靶标的用途的最新知识。关于本文描述的用于AD的蛋白质和miRNA生物标志物候选物的最新发现突出了该领域的技术水平，并鼓励在不久的将来在临床实践中使用源自生物流体的外泌体。

更新日期：2020-07-03

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