Perioperative administration of desmopressin has shown to significantly decrease rates of local recurrence and metastasis, and increase survival times in dogs with grade II and III mammary carcinomas. The objective of this study was to compare the oncologic outcome of cats with mammary carcinoma treated with bilateral mastectomy with or without perioperative administration of desmopressin. Medical records from nine veterinary institutions were searched to identify cats diagnosed with mammary carcinoma treated with bilateral mastectomy. Sixty cats treated with single-session or staged bilateral mastectomy were included. There were no significant differences in oncologic outcomes found between cats treated and not treated with desmopressin. No adverse effects were seen in any of the cats treated with perioperative desmopressin. Postoperative complications occurred in 18 cats (38.3%) treated with single-session bilateral mastectomy and in three cats (23.1%) treated with staged bilateral mastectomy (P = .48). Histologic grade and a modification of a proposed five-stage histologic staging system were both prognostic for disease-free interval. Incomplete histologic excision was associated with significantly increased rates of metastasis and tumour progression, and a shorter median survival time (MST). Cats that developed local recurrence also had a significantly shorter MST. The results of this study do not support the use of perioperative desmopressin to improve outcome when performing bilateral mastectomy for the treatment of mammary carcinoma in cats.

中文翻译：

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双侧乳房切除术治疗猫乳腺癌围手术期去氨加压素的效果

围手术期给予去氨加压素已显示显着降低局部复发和转移率，并增加患有 II 级和 III 级乳腺癌的狗的存活时间。本研究的目的是比较双侧乳房切除术治疗患有乳腺癌的猫在有或没有围手术期给予去氨加压素的情况下的肿瘤学结果。搜索了来自 9 个兽医机构的医疗记录，以识别被诊断患有乳腺癌并接受双侧乳房切除术治疗的猫。包括 60 只接受单次或分期双侧乳房切除术治疗的猫。在接受去氨加压素治疗和未接受去氨加压素治疗的猫之间发现的肿瘤学结果没有显着差异。在围手术期使用去氨加压素治疗的任何猫中均未观察到不良反应。P  = .48)。组织学分级和提议的五期组织学分期系统的修改都是无病间隔的预后。不完全组织学切除与转移率和肿瘤进展率显着增加以及中位生存时间（MST）更短有关。出现局部复发的猫的 MST 也显着缩短。这项研究的结果不支持在进行双侧乳房切除术治疗猫乳腺癌时使用围手术期去氨加压素来改善结果。