Comprehensive Phenotyping of Human PB NK Cells by Flow Cytometry

The NK cell compartment provides powerful innate defenses against virus‐infected and tumor cells. Specific NK cell receptors control this process and maintain the immune system homeostasis and prevent autoimmunity. A wide variety of NK cell subsets with different functional capabilities exist and this reflects not only the different maturation stages of NK cells but also different microenvironments in which they can operate. In a recent issue of Cytometry Part A , Del Zotto et al. give an overview on the various NK cell subsets present in peripheral blood of healthy donors in order to clearly and univocally identify them on the basis of their phenotypic traits using flow cytometry.

Genny Del Zotto et al.

Cytometry Part A , 2020

DOI: https://doi.org/10.1002/cyto.a.24001

流式细胞术对人PB NK细胞的综合表型

NK细胞区隔提供了强大的先天防御能力，可以抵抗病毒感染的细胞和肿瘤细胞。特定的NK细胞受体控制着这一过程，并维持免疫系统的稳态并防止自身免疫。存在具有不同功能能力的各种各样的NK细胞亚群，这不仅反映了NK细胞的不同成熟阶段，而且反映了它们可以在其中运行的不同微环境。在最近一期的《细胞计数法》第A部分中，Del Zotto等人。简要概述了健康供体外周血中存在的各种NK细胞亚群，以便使用流式细胞仪根据其表型特征明确，唯一地识别它们。

Genny Del Zotto等。

细胞计量A部分，2020

DOI：https：//doi.org/10.1002/cyto.a.24001