Recent in vitro evidence suggests that the phytol‐derived fatty acids, phytanic acid (PA) and pristanic acid (PrA), are components of animal products with the potential to cause both beneficial and harmful effects on human health. In this study, we investigated the in vivo tissue accumulation of PA and PrA and the changes in tissue lipid profiles, using mice fed a phytol‐containing diet. After 4 weeks of treatment with a diet containing 1.0% phytol, plasma, adipose tissue, liver, and brain were collected and their lipid profiles were biochemically and gas‐chromatographically determined. Dietary phytol caused PA and PrA accumulation in the adipose tissue and liver but not in the brain, and reduced plasma and liver triacylglycerol levels. Phytol intake also decreased the fatty acid concentrations in the adipose tissue, especially polyunsaturated fatty acids such as linoleic acid, but increased the concentrations of these fatty acids in the liver. However, dietary phytol had a low impact on the brain lipid profile. This study suggests that dietary phytol intake caused accumulation of PA and PrA and modified lipid profiles in the adipose tissue and liver, but that the brain is an insusceptible tissue to dietary phytol‐induced changes.

中文翻译：

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日粮叶绿醇对植烷酸和猴头酸组织积累以及小鼠组织脂质分布的影响。

最近的体外证据表明，植醇衍生的脂肪酸、植烷酸 (PA) 和鹦鹉螺酸 (PrA) 是动物产品的成分，可能对人类健康产生有益和有害的影响。在这项研究中，我们使用含叶绿醇饮食的小鼠研究了 PA 和 PrA 的体内组织积累以及组织脂质分布的变化。在用含有 1.0% 叶绿醇的饮食治疗 4 周后，收集血浆、脂肪组织、肝脏和大脑，并通过生化和气相色谱法测定它们的脂质谱。膳食叶绿醇导致 PA 和 PrA 在脂肪组织和肝脏中积累，但在大脑中没有，并降低血浆和肝脏三酰甘油水平。叶绿醇的摄入也降低了脂肪组织中的脂肪酸浓度，尤其是亚油酸等多不饱和脂肪酸，反而增加了这些脂肪酸在肝脏中的浓度。然而，膳食叶绿醇对脑脂质分布的影响很小。这项研究表明，膳食叶绿醇的摄入导致脂肪组织和肝脏中 PA 和 PrA 的积累以及脂质分布的改变，但大脑是一个不易受膳食叶绿醇诱导的变化的组织。