Silver nanoparticles (AgNPs) have been proposed to combat oral infection due to their efficient ionic silver (Ag⁺) release. However, concentrations required for antimicrobial efficacy may not be therapeutically viable. In this work, platinum‐doped silver nanoparticles (Pt‐AgNPs) were explored to evaluate their potential for enhanced Ag⁺ release, which could lead to enhanced antimicrobial efficacy against S. aureus, P. aeruginosa, and E. coli. AgNPs doped with 0.5, 1, and 2 mol% platinum (Pt_0.5‐AgNPs, Pt₁‐AgNPs, and Pt₂‐AgNPs) were synthesized by a chemical reduction method. Transmission electron microscopy revealed mixed morphologies of spherical, oval, and ribbon‐like nanostructures. Surface‐enhanced Raman scattering revealed that the surface of Pt‐AgNPs was covered with up to 93% Pt. The amount of Ag⁺ released increased 16.3‐fold for Pt₂‐AgNPs, compared to AgNPs. The initial lag phase in bacterial growth curve was prolonged for Pt‐AgNPs. This is consistent with a Ag⁺ release profile that exhibited an initial burst followed by sustained release. Doping AgNPs with platinum significantly increased the antimicrobial efficacy against all species. Pt₂‐AgNPs exhibited the lowest minimum inhibitory concentrations, followed by Pt₁‐AgNPs, Pt_0.5‐AgNPs, and AgNPs, respectively. Doping AgNPs with a small amount of platinum promoted the release of Ag⁺, based on the sacrificial anodic effect, and subsequently enhanced their antimicrobial efficacy.

中文翻译：

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铂掺杂银纳米颗粒的抗菌功效。


银纳米粒子（AgNP）由于其有效释放离子银（Ag ⁺ ）而被提议用于对抗口腔感染。然而，抗菌功效所需的浓度可能在治疗上不可行。在这项工作中，研究人员探索了掺铂银纳米粒子（Pt-AgNPs），以评估其增强Ag ⁺释放的潜力，这可能会增强对金黄色葡萄球菌的抗菌功效。金黄色葡萄球菌， P .铜绿假单胞菌和大肠杆菌。大肠杆菌。通过化学还原法合成了掺杂 0.5、1 和 2 mol% 铂的 AgNP（Pt _0.5 -AgNP、Pt ₁ -AgNP 和 Pt ₂ -AgNP）。透射电子显微镜显示出球形、椭圆形和带状纳米结构的混合形态。表面增强拉曼散射显示 Pt-AgNPs 的表面被高达 93% 的 Pt 覆盖。与 AgNP 相比，Pt ₂ -AgNP 释放的 Ag ⁺量增加了 16.3 倍。 Pt-AgNPs 的细菌生长曲线的初始滞后期延长。这与 Ag ⁺释放曲线一致，Ag + 释放曲线表现出最初的爆发，然后是持续释放。用铂掺杂 AgNP 显着提高了对所有物种的抗菌功效。 Pt ₂ -AgNPs 表现出最低的最小抑制浓度，其次是 Pt ₁ -AgNPs、Pt _0.5 -AgNPs 和 AgNPs。在AgNPs中掺杂少量铂，基于牺牲阳极效应，促进Ag ⁺的释放，从而增强其抗菌功效。